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发明授权
CN1902312B 制备导入了基因的树突细胞的方法 失效 - 权利终止

制备导入了基因的树突细胞的方法
摘要：
本发明提供用于向树突细胞导入基因的方法，其包括将负链RNA病毒与树突细胞接触的步骤。本发明也提供制备导入了基因的树突细胞的方法，其包括将负链RNA病毒与树突细胞接触的步骤。本发明还提供用这种方法制备的导入了基因的树突细胞。本发明提供激活树突细胞的方法，其包括将负链RNA病毒与树突细胞接触的步骤。本发明使向树突细胞有效导入基因成为可能。导入了抗原基因或细胞因子基因的树突细胞作为疫苗是有用的。
摘要（英）：

It is intended to provide a method of transferring a gene into a dendritic cell which comprises the step of contacting a minus strand RNA virus with the dendritic cell; a method of constructing a transgenic dendritic cell which comprises the step of contacting a minus strand RNA virus with the dendritic cell; a transgenic dendritic cell constructed by this method; and a method of activating a dendritic cell which comprises the step of contacting a minus strand RNA virus with the dendritic cell. Thus, it becomes possible to efficiently deliver a gene into a dendritic cell. A dendritic cell having an antigen gene or a cytokine gene transferred thereinto is useful as a vaccine.

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