A remote tire pressure monitoring system includes a tire monitor, a receiver, a transmitter, and a controller. The tire monitor is configured to operate in a power saving mode, in which it senses inflation pressure of a tire, determines a change in the inflation pressure of the tire, and transmits a pressure transmitting signal only when the determined change in the inflation pressure is greater than or equal to a predetermined threshold. The controller is operatively connected with the receiver and the transmitter. The controller works to determine, upon receipt of the pressure transmitting signal by the receiver, the inflation pressure of the tire based on the pressure transmitting signal. The controller also works to control, in response to receipt of the pressure transmitting signal by the receiver, the transmitter to transmit the acknowledge signal to inform the tire monitor that the receiver has certainly received the pressure transmitting signal.