The utility model discloses a cell electrophysiological integrated chip. An MEA microelectrode array is integrated in the center of the front face of a Si substrate, an IDA interdigital electrode and an LAPS light addressable potentionmetric sensor are respectively integrated on bilateral sides of the MEA microelectrode array, and reference electrodes are symmetrically arranged on the other bilateral sides of the MEA microelectrode array. The integrated chip can simultaneously detect the adherent cells growth state, action potential and concentration of various ions in products of cell metabolism, is used for realizing simultaneous parallel detection of multi-parameter, overcomes the core technical difficulty of designing and processing integrated cell sensor chips, and widens novel application areas for developing portability and instrumentation of intergraded cell sensing technology.