The utility model discloses a resorcinol neutralization-reaction device and relates to a reaction device for a mixer at a resorcinol neutralization-reaction section, which solves the problems of high energy-source consumption, a large amount of solid wastes and the like in the production process of traditional isophthalic sulfonic acid sodium salt, isophthalic sulfonic acid and liquid alkali are conveyed into a static mixer for neutralization reaction through a metering pump, and a generated material is heated and the water is evaporated by utilizing the heat generated by neutralization to directly form the high-temperature powdery isophthalic sulfonic acid sodium salt to be used for a resorcinol alkali-fusion section. In the utility model, acid and alkali neutralization and drying synchronization is adopted for the reaction, the drying is quick and complete, the purpose of continuous production is realized, and meanwhile, the utilization ratio of energy sources is increased, and the generation of the solid wastes is reduced.