The utility model provides a medicine bottle with a pronunciation instruction book, which aims at solving the problem that gerontal patients are difficult to see small characters on the medicine bottle and small characters on the instruction book in the medicine bottle. The technical scheme is that the medicine bottle comprises a bottle body, an inner cover, an outer cover and a loudspeaker with a pronunciation chip, the inner cover is plugged in a bottle opening of the bottle body, the outer cover is rotatably connected with the bottle opening of the bottle body, the loudspeaker with the pronunciation chip is arranged between the inner cover and the outer cover, and a power switch is arranged on the loudspeaker with the pronunciation chip. The instruction book is printed on the surface of the bottle body, and the loudspeaker with the pronunciation chip is further arranged in the bottom cover and provides the pronunciation instruction book. The presbyopic gerontal patients do not need see the printed instruction book and can hear using instructions of medicines in the bottle body by pushing the switch on the loudspeaker with the pronunciation chip, so that the medicine bottle brings huge convenience to the gerontal patients.