A double-limit screw clearance self-adjusting device comprises a screw, stop pins and a limit groove, and is characterized in that the two stop pins are symmetrically designed around the center line of the screw. The screw of the double-limit screw clearance self-adjusting device is more stable during usage, a clearance adjusting function is guaranteed, the stability of the clearance self-adjusting function is enhanced, the problem of braking deviation due to the fact that brake clearances on two sides are inconsistent and braking periods are different is prevented, and the safety of an integral vehicle is improved. In addition, the problem of stressed abrasion on a single side is eliminated, the service life of a product is prolonged, and replacement and maintenance costs of the product are reduced.