The utility model relates to a load-isolating switch box for crossing power substations to supply power, which comprises a box body. A first isolating switch and a second isolating switch which are connected in series are arranged in the box body; the first isolating switch is connected with a power through line fed out in one direction of the power substations; and the second isolating switch is connected with a power through line fed out in the other direction of the power substations. The load-isolating switch box has a simple structure and is convenient to use; and the crossing power supply among different power substations can be implemented only by simply switching on or switching off the first isolating switch and the second isolating switch so as to meet the power supply requirement of the railway power substations.