The utility model is applicable to the field of PCB processing equipment, and provides a PCB replacing device. The device comprises a support plate and two sucker mechanisms. Each sucker mechanism includes a first support rod and a second support rod which are arranged in parallel and spaced from each other; a plurality of connection blocks mounted on the first support rod and the second support rod; and suction nuzzles correspondingly mounted on the connection blocks and used for sucking and placing the PCB. The two sucker mechanisms are mounted at the upper and lower ends of the support plate, respectively, and are in back-to-back arrangement. The PCB replacing device further comprises a turnover mechanism which is fixedly connected with the support plate and used for driving the support plate to rotate so as to drive the two sucker mechanisms to be turned over, and a lifting mechanism which is used for driving the turnover mechanism to move up and down so as to drive the two sucker mechanisms to move up and down. Compared with the prior art, the PCB replacing device has the advantages of simple procedures and high efficiency.