The utility model relates to an angle-adjustable operating knife comprising a front-back telescopic rotary button, an angle adjusting rotary button, a hard plastic pipe sleeve, a needle core pipe, side-wing blades and a slide centering sleeve. Two side-wing blades are provided and fixed on the needle core pipe; the needle core pipe passes through the centering sleeve and is connected with the front-back telescopic rotary button; the angle adjusting rotary button is arranged on the hard plastic pipe sleeve; and one end of the hard plastic pipe sleeve is provided with the front-back telescopic rotary button. The angle-adjustable operating knife is simply structured with rational design; by the use of the angle-adjustable operating knife, an angle can be adjusted for the operating as required as a patient during erection of penis operation; the angle-adjustable operating knife can be conveniently operated, so doctor operation difficulty can be reduced; the patient operation incision cannot be bonded in short time; and blood circulation and body health can be facilitated.