The invention discloses a fatigue driving detection device based on a prefrontal lobe electroencephalogram and a 3D (three dimensional) acceleration gyroscope. The device comprises a gyroscope sensor, an electroencephalogram sensor, an acceleration sensor, an analysis processing module, a cell and a switch, a Bluetooth module, wherein the gyroscope sensor, the electroencephalogram sensor, and the acceleration sensor are the sensor units of the device; the gyroscope sensor, the electroencephalogram sensor, and the acceleration sensor are connected with the analysis processing module respectively; the cell and the switch are connected with the analysis processing module, a Bluetooth port is arranged on the analysis processing module, and the analysis processing module is connected with the Bluetooth module. The mobile terminal device is interacted with the analysis processing module through the analysis processing module. The electroencephalogram sensor comprises two plastic ear clips and a forehead plaster electrode.