The utility model relates to a disposable brain-targeted drug delivery device via the nose. The disposable brain-targeted drug delivery device via the nose comprises a drug delivery device body which comprises a container which is provided with an inner cavity and used for storing a preparation, a catheter which is communicated with the container and used for guiding the preparation in the container into the nasal cavity and a spray head arranged at one end of the catheter, and the end of the catheter can extend into the nasal cavity olfactory area above the horizontal position corresponding to the concha nasalis media through the meatus nasi communis of the human body; the drug delivery device body further comprises a pressure sensitive membrane which is arranged in the container, divides the inner cavity of the container into multiple independent chambers and is ruptured under the pressure action, the other end of the catheter is connected with one of the multiple chambers, and the drug delivery device body further comprises a soluble membrane which is used for separating the catheter cavity of the catheter from the chamber connected with the catheter cavity and can be partially or fully dissolved after making contact with the preparation. By means of the drug delivery device, the preparation can be efficiently delivered to the nasal cavity olfactory area and then absorbed into the brain directly and play a role in treating the central nervous system.