The utility model relates to a disposable brain-targeted drug delivery device via the nose. The disposable brain-targeted drug delivery device via the nose comprises a drug delivery device body which comprises a catheter and a spray head arranged at one end of the catheter, the drug delivery device body further comprises an injector which is provided with an inner cavity and used for storing a preparation, the other end of the catheter is connected to the injector and communicated with the inner cavity of the injector, and the end, provided with the spray head, of the catheter can extend into the nasal cavity olfactory area above the horizontal position corresponding to the concha nasalis media through the meatus nasi communis of the human body; the drug delivery device body further comprises a pressure sensitive membrane which is used for separating the inner cavity of the injector from the catheter cavity of the catheter and is ruptured under the pressure action. By means of the drug delivery device, the preparation can be efficiently delivered to the nasal cavity olfactory area and then absorbed into the brain directly and play a role in treating the central nervous system.