The utility model discloses an appearance is hybridized to full -automatic nucleic acid molecules, a serial communication port, but including casing, circuit control module, hybridization platform, three -dimensional moving platform, multichannel application of sample piston device, tip head and touch screen monitor. The utility model discloses an advantage: 1. Hybridize the process full automatization, need not manual operation, save the labour, shorten the run time, reduce experimentation human factor mistake, 2. Adopt the three -dimensional moving platform, the quick travel position, moving accuracy is high, accurate, 3. Can carry out the experiment of many person -portions simultaneously, can avoid cross infection again, shorten the run time, 4. The tip head divides two types sizes as required, and big tip head adopts the big volume of inhaling design, absorbs and once to realize 5 continuous accurate application of samples, simplifies the experimentation, shortens the run time.