The utility model discloses a medicine storage device of multiple protection, the device include bottle and bottle lid, are equipped with the bottleneck on the bottle, and the bottle lid is the hollowcircular cylinder that the upper surface is complete, and the hollow portion of bottle lid and bottleneck phase -match, bottle lid and bottleneck match when covering closely, and the hollow portion internal surface of bottle lid is higher than and is equipped with the gas pocket on the side of bottleneck, the drier cell that is equipped with the drier is established respectively at the non - cavity position of bottle lid, is equipped with antioxidant's antioxidant cell and the chelating agent cell that is equipped with the chelating agent. The utility model discloses a three cell, have good sealed protection against the tide, anti -oxidant and chela and multiple protective properties, three cell is located the bottleneck outside simultaneously, has improved the security for the conventionality mode of placing in current bottle cap inner side and the bottle, and need not to occupy the parking space of medicine, can effectively prolong the life of medicine.