The utility model provides a portable thermometer disinfection device, and belongs to the field of medical equipment. The device comprises a handle, a shell, a cleaning tank body and a disinfection tank body, the handle is in balanced connection with two sides of the shell; the cleaning tank body and the disinfection tank body are correspondingly arranged in the first circular groove and the second circular groove; the annular groove is located in the side, opposite to the circular groove, of the circular groove. the folder is arranged in the annular groove; a body thermometer fixing device isarranged above the cleaning tank body and the disinfection tank body; a cylindrical through hole is formed in the body thermometer fixing device, the size of the cylindrical through hole of the bodythermometer fixing device is the same as that of the body thermometer, the body thermometer fixing device is used for containing the body thermometer, a semicircular annular groove is formed in the same side of the cleaning tank body and the disinfection tank body, and cylindrical drying sponge and cylindrical disinfection sponge are correspondingly installed at the bottom of the cleaning tank body and the bottom of the disinfection tank body. According to the utility model, disinfection and cleaning modes are integrated, and disinfection and drying processes are carried out in the extractionprocess of the thermometer, so that the thermometer is simpler and more labor-saving.