The utility model discloses a large-drift-diameter waterproof oil production packer. The hydraulic seal feeding tool comprises an external hydraulic cylinder, a transition sleeve and a transition mandrel, the hydraulic cylinder is arranged at the upper end of the transition sleeve and used for separating a seal feeding tubular column after setting, the transition sleeve is arranged on the transition mandrel in a sleeving mode and used for being connected with a setting anchoring mechanism, and the lower end of the transition mandrel is connected with the large-drift-diameter packer. The large-drift-diameter packer comprises a first center pipe, the upper end and the lower end of the first center pipe are each provided with a fine-tooth slip, the directions of clamping teeth are opposite, and a plurality of rubber sleeves are evenly distributed on the first center pipe at intervals. The sealing inserting pipe is arranged on the second center pipe in a sleeving mode and used for being inserted into the large-drift-diameter packer after the large-drift-diameter packer is successfully released. The packer can be effectively prevented from being frequently unsealed and replaced due to pump inspection, measure operation and other reasons, one-time governance can be achieved within the validity period of the packer, the packer can be repeatedly used within the validity period, and theisolated mining workload and governance cost are reduced.