The utility model relates to a hand-operated vertical rotary lifting type protective sealing door, which is a protective sealing door for a large size tunnel civil defense project. The utility model comprises a door leaf (1), a door frame (16), a hinge mechanism, a blocking mechanism, a resetting mechanism, a wicket (15) and a trench cover board. The utility model is characterized in that the hinge mechanism uses a four hinge seat lifting mechanism of which the upright shaft (4) is supported by four hinge seats (3) which is fixedly connected with the door frame (16) and can reduce the internal force of the upright shaft (4), and a guiding seat (8) which can ensure the stability of a pressed rod is arranged between an upper pressed rod (7) of the blocking mechanism and a hand wheel (10). Furthermore, H-shaped steel which can improve the bonding property of a preembedded piece and coating cover asphalt of a road surface is used by a lower doorsill and a preembedded piece of a door slot, wherein, the lower doorsill and the preembedded piece are arranged in the trench. The utility model has the advantages of reasonable and safe structure, portable and rapid operation, such as the opening, the closing, the lifting and the unlocking and the locking of a lock, of the door leaf and little rebound force of the door leaf, and besides, nearly 20 tons of a single door leaf only needs 28 kgf hand push to a position. At ordinary time, a horizontal section is not arranged before a door so as to lead to no influences of the moving comfort degree of vehicles. At war time, the utility model can prevent nuclear explosion or impact waves of bombs, radioactive contamination, biochemistry toxic agents, etc. from entering the inner part of underground construction.