发明公开
EP0001019A1 Phenylhydrazones, their use in insecticidal compositions and methods for their preparation
失效
苯肼，re。ung。。。。。。。。。。。。。。。。。。。。。。。。。。。
- 专利标题： Phenylhydrazones, their use in insecticidal compositions and methods for their preparation
- 专利标题（中）： 苯肼，re。ung。。。。。。。。。。。。。。。。。。。。。。。。。。。
-
申请号： EP78300327.0申请日： 1978-08-29
-
公开(公告)号： EP0001019A1公开(公告)日： 1979-03-07
- 发明人: Holan, George
- 申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
- 申请人地址： 407 Royal Parade Parkville, VIC 3052 AU
- 专利权人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
- 当前专利权人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
- 当前专利权人地址： 407 Royal Parade Parkville, VIC 3052 AU
- 代理机构： Lawrence, Peter Robin Broughton
- 优先权： AU1437/77 19770829
- 主分类号： C07C109/14
- IPC分类号： C07C109/14 ; A01N9/20
摘要：
Compounds of the general formula
wherein R 1 , R 2 , R'. R 4 and R 5 are each independently H, Cl, Br. NO 2 or CF 3 ; X = H or Br; and Z is H, CH 3 or CF 3 .
The compounds are all potent inhibitors of oxidative phosphorylation in rat liver mitochondria and have other biological activity, for example, insecticidal activity.
The compounds are made (A) where X = H and Z = CF 3 . by reacting the appropriately substituted phenylhydrazine with hexafluoroacetone in a basic organic solvent in the presence of an acidic dehydrating agent; (b) where X = H and Z is H or CH 3 by reaction of the phenylhydrazine with 1,1,1-trifluoroacetone or trifluoroacetaldehyde in a suitable solvent in the presence of an acid catalyst: (c) where X = Br can be made from the corresponding compound where X = H by direct bromination.
The invention includes insecticidal compositions containing the compounds.
wherein R 1 , R 2 , R'. R 4 and R 5 are each independently H, Cl, Br. NO 2 or CF 3 ; X = H or Br; and Z is H, CH 3 or CF 3 .
The compounds are all potent inhibitors of oxidative phosphorylation in rat liver mitochondria and have other biological activity, for example, insecticidal activity.
The compounds are made (A) where X = H and Z = CF 3 . by reacting the appropriately substituted phenylhydrazine with hexafluoroacetone in a basic organic solvent in the presence of an acidic dehydrating agent; (b) where X = H and Z is H or CH 3 by reaction of the phenylhydrazine with 1,1,1-trifluoroacetone or trifluoroacetaldehyde in a suitable solvent in the presence of an acid catalyst: (c) where X = Br can be made from the corresponding compound where X = H by direct bromination.
The invention includes insecticidal compositions containing the compounds.
信息查询
