发明公开
EP0001149A1 Process for the preparation of 3-bromomethyl-3-cephem-sulphoxide derivatives
失效
Verfahren zur Herstellung von 3-Bromomethyl-3-cephem-sulfoxyd-derivaten。
- 专利标题： Process for the preparation of 3-bromomethyl-3-cephem-sulphoxide derivatives
- 专利标题（中）： Verfahren zur Herstellung von 3-Bromomethyl-3-cephem-sulfoxyd-derivaten。
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申请号： EP78200174.7申请日： 1978-09-06
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公开(公告)号： EP0001149A1公开(公告)日： 1979-03-21
- 发明人: Bruynes, Cornelis Adrianus , De Koning, Jan Jacobus
- 申请人： GIST-BROCADES N.V.
- 申请人地址： Wateringseweg 1 P.O. Box 1 NL-2600 MA Delft NL
- 专利权人： GIST-BROCADES N.V.
- 当前专利权人： GIST-BROCADES N.V.
- 当前专利权人地址： Wateringseweg 1 P.O. Box 1 NL-2600 MA Delft NL
- 代理机构： Mars, Pieter
- 优先权： GB3741377 19770907
- 主分类号： C07D501/24
- IPC分类号： C07D501/24 ; C07D501/00
摘要：
Improved process for the preparation of brominated cephalosporanic derivatives, wherein a desacetoxy-3-cephem sulphoxide of general formula
wherein R 1 represents an acylamido group and R 3 represents a group protecting the carboxy radical, is brominated in manner known per se and a compound of general formula
in the reaction mixture or separated from such a reaction mixture is debrominated in the presence of a hydrogen donor and the 3-bromomethyl-3- cephem derivative of the general formula
thus produced is recovered.
wherein R 1 represents an acylamido group and R 3 represents a group protecting the carboxy radical, is brominated in manner known per se and a compound of general formula
in the reaction mixture or separated from such a reaction mixture is debrominated in the presence of a hydrogen donor and the 3-bromomethyl-3- cephem derivative of the general formula
thus produced is recovered.
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