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    New intermediates for the preparation of cephalosporins and process for the preparation of the intermediates
    3.
    发明公开
    New intermediates for the preparation of cephalosporins and process for the preparation of the intermediates 失效
    中间体头孢菌素的制备方法和用于制备这些中间体。

    公开(公告)号：EP0015629A1

    公开(公告)日：1980-09-17

    申请号：EP80200215.4

    申请日：1980-03-06

    申请人： GIST-BROCADES N.V.

    发明人： Bruynes, Cornelis Adrianus

    IPC分类号： C07F7/10

    CPC分类号： C07D501/04 ,  C07F7/18

    摘要： New bromo-substituted deacetoxycephalosporins, of the general formula:
    wherein R, represents a benzamido, formamido, phenylacetamido or phenoxyacetamido group, R 2 represents a hydrogen or bromine atom and R 3 represents a silyl group of the general formula:
    wherein R', R" and R"' are the same or different and each represents an alkyl group (having at most 6 carbon atoms), a halogen-substituted alkyl group (having at most 6 carbon atoms) or an aryl group and process for the preparation of the compounds of formula I.
    The compounds of formula I are suitable intermediates in processes for the preparation of known and new antibiotics.

    摘要翻译： 通式新溴substituiertem deacetoxycephalosporins：... ... worin R1 darstellt一个苯甲酰氨基，甲酰胺基，苯乙酰胺基或苯氧基，R2 darstellt氢原子或溴原子和R 3 darstellt一个甲硅烷基的通式为：... ... worin R1，R秒和R“”“是相同的或不同的，各自darstellt到烷基（具有至多6个碳原子），卤素取代的烷基（具有至多6个碳原子）或芳基和 对于式I的化合物的制备方法，... 式I化合物在制备用于已知的或新的抗生素的制备方法适宜的中间体。

    Process for the preparation of 3-bromomethyl-3-cephem-sulphoxide derivatives
    5.
    发明公开
    Process for the preparation of 3-bromomethyl-3-cephem-sulphoxide derivatives 失效
    Verfahren zur Herstellung von 3-Bromomethyl-3-cephem-sulfoxyd-derivaten。

    公开(公告)号：EP0001149A1

    公开(公告)日：1979-03-21

    申请号：EP78200174.7

    申请日：1978-09-06

    申请人： GIST-BROCADES N.V.

    发明人： Bruynes, Cornelis Adrianus ,  De Koning, Jan Jacobus

    IPC分类号： C07D501/24 ,  C07D501/00

    CPC分类号： C07D501/04 ,  Y02P20/582

    摘要： Improved process for the preparation of brominated cephalosporanic derivatives, wherein a desacetoxy-3-cephem sulphoxide of general formula
    wherein R 1 represents an acylamido group and R 3 represents a group protecting the carboxy radical, is brominated in manner known per se and a compound of general formula
    in the reaction mixture or separated from such a reaction mixture is debrominated in the presence of a hydrogen donor and the 3-bromomethyl-3- cephem derivative of the general formula
    thus produced is recovered.

    摘要翻译： 制备溴代头孢菌素衍生物的改进方法，其中通式为...的其中R 1表示酰基酰胺基，R 2表示保护羧基的基团的脱乙酸基-3-头孢烯亚砜以本身已知的方式进行溴化， 将反应混合物中的通式为...的化合物或与该反应混合物分离的化合物在氢供体和通式为...的3-溴甲基-3-头孢烯衍生物的存在下脱溴...因此 产生回收。