发明公开
EP0015776A1 1,1'-Biphenyl-2-yl alkylamine derivatives, their production and cardiovascular preparations containing same
失效
1,1'-联苯-2-基 - 烷基氨基 - 衍生物，其中Herstellung und sie enthaltende kardiovaskularePräparate。
- 专利标题： 1,1'-Biphenyl-2-yl alkylamine derivatives, their production and cardiovascular preparations containing same
- 专利标题（中）： 1,1'-联苯-2-基 - 烷基氨基 - 衍生物，其中Herstellung und sie enthaltende kardiovaskularePräparate。
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申请号： EP80300744.2申请日： 1980-03-11
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公开(公告)号： EP0015776A1公开(公告)日： 1980-09-17
- 发明人: Lacefield, William Bryant , Simon, Richard Lee
- 申请人： ELI LILLY AND COMPANY
- 申请人地址： 307, East McCarty Street Indianapolis Indiana 46285 US
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： 307, East McCarty Street Indianapolis Indiana 46285 US
- 代理机构： McVey, Kenneth William Henry
- 优先权： US19534 19790312
- 主分类号： C07C91/16
- IPC分类号： C07C91/16 ; C07D295/08 ; C07C87/28 ; C07C103/18 ; C07C101/30 ; C07C91/26 ; C07C121/66 ; A61K31/135 ; A61K31/16 ; A61K31/195 ; A61K31/275
摘要：
1,1'-biphenyl-2-yl alkylamine derivatives of formula (I):
wherein:
X is hydrogen or a halo substituent at any position in the phenyl ring;
R 1 is hydrogen, hydroxy, C≡N, CONR 5 R 6 , or CO 2 R 8 where R 5 , R 6 , R 8 independently represent hydrogen or alkyl;
R 2 is hydrogen or alkyl;
where n is an integer of from 2 to 4;
R 3 and R 4 independently are hydrogen, C 1-6 alkyl, CH 2 C 2-5 alkenyl, phenyl C 1-3 alkyl, or taken together with the adjacent nitrogen atom form a heterocyclic group or a pharmaceutically-acceptable salt thereof.
The compounds are prepared by the usual methods for analogous compounds. They have been found to be effective in the treatment of cardiac arrhythmias. Pharmaceutical formulations have been prepared.
wherein:
X is hydrogen or a halo substituent at any position in the phenyl ring;
R 1 is hydrogen, hydroxy, C≡N, CONR 5 R 6 , or CO 2 R 8 where R 5 , R 6 , R 8 independently represent hydrogen or alkyl;
R 2 is hydrogen or alkyl;
where n is an integer of from 2 to 4;
R 3 and R 4 independently are hydrogen, C 1-6 alkyl, CH 2 C 2-5 alkenyl, phenyl C 1-3 alkyl, or taken together with the adjacent nitrogen atom form a heterocyclic group or a pharmaceutically-acceptable salt thereof.
The compounds are prepared by the usual methods for analogous compounds. They have been found to be effective in the treatment of cardiac arrhythmias. Pharmaceutical formulations have been prepared.
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