发明公开
EP0021121A1 1,2,4-Triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
失效
1,2,4-三嗪衍生物，用于制备这些化合物和含有它们的药物组合物。
- 专利标题： 1,2,4-Triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
- 专利标题（中）： 1,2,4-三嗪衍生物，用于制备这些化合物和含有它们的药物组合物。
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申请号： EP80103032.1申请日： 1980-05-30
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公开(公告)号： EP0021121A1公开(公告)日： 1981-01-07
- 发明人: Baxter, Martin George , Elphick, Albert Reginald , Miller, Alistair Ainslie , Sawyer, David Alan
- 申请人： THE WELLCOME FOUNDATION LIMITED
- 申请人地址： Unicorn House 160 Euston Road P.O. Box 129 London NW1 2BP GB
- 专利权人： THE WELLCOME FOUNDATION LIMITED
- 当前专利权人： THE WELLCOME FOUNDATION LIMITED
- 当前专利权人地址： Unicorn House 160 Euston Road P.O. Box 129 London NW1 2BP GB
- 代理机构： Berg, Wilhelm, Dr.
- 优先权： GB7919257 19790601
- 主分类号： C07D253/06
- IPC分类号： C07D253/06 ; A61K31/53
摘要：
The present invention provides compounds of the formula (III):
or an acid addition salt thereof, wherein R 6 is chlorine, bromine, iodine, C 1 - 4 alkyl or trifluoromethyl, R 7 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl or R 6 and R 7 form a -CH=CH-CH=CH- group optionally substituted by a halogen atom or a C 1-4 alkyl or trifluoromethyl group, R 8 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl, R 9 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl, R 10 is hydrogen, methyl or fluorine and R" is amino, C 1-4 acylamino or di-substituted aminomethyleneamino provided that, at most, only two of R 7 ―R 10 are other than hydrogen and that R 7 ―R 10 are not all hydrogen when R 6 is chlorine. Also provided are pharmaceutical compositions containing compounds of the formula (III), the first medical use of compounds of the formula (III), a process for preparing such compounds and intermediates through which this process proceeds.
or an acid addition salt thereof, wherein R 6 is chlorine, bromine, iodine, C 1 - 4 alkyl or trifluoromethyl, R 7 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl or R 6 and R 7 form a -CH=CH-CH=CH- group optionally substituted by a halogen atom or a C 1-4 alkyl or trifluoromethyl group, R 8 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl, R 9 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl, R 10 is hydrogen, methyl or fluorine and R" is amino, C 1-4 acylamino or di-substituted aminomethyleneamino provided that, at most, only two of R 7 ―R 10 are other than hydrogen and that R 7 ―R 10 are not all hydrogen when R 6 is chlorine. Also provided are pharmaceutical compositions containing compounds of the formula (III), the first medical use of compounds of the formula (III), a process for preparing such compounds and intermediates through which this process proceeds.
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