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公开(公告)号：EP0059987B1
公开(公告)日：1985-08-14
申请号：EP82102293.6
申请日：1980-05-30
发明人： Baxter, Martin George , Elphick, Albert Reginald , Miller, Alistair Ainslie , Sawyer, David Alan
IPC分类号： C07C133/12
CPC分类号： C07D253/075 , C07C51/15 , C07C51/363 , C07C255/00 , C07C281/18 , C07C63/70
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2.发明公开1,2,4-Triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them 失效1,2,4-三嗪衍生物，用于制备这些化合物和含有它们的药物组合物。
公开(公告)号：EP0021121A1
公开(公告)日：1981-01-07
申请号：EP80103032.1
申请日：1980-05-30
发明人： Baxter, Martin George , Elphick, Albert Reginald , Miller, Alistair Ainslie , Sawyer, David Alan
IPC分类号： C07D253/06 , A61K31/53
CPC分类号： C07D253/075 , C07C51/15 , C07C51/363 , C07C255/00 , C07C281/18 , C07C63/70
摘要： The present invention provides compounds of the formula (III):
or an acid addition salt thereof, wherein R 6 is chlorine, bromine, iodine, C 1 - 4 alkyl or trifluoromethyl, R 7 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl or R 6 and R 7 form a -CH=CH-CH=CH- group optionally substituted by a halogen atom or a C 1-4 alkyl or trifluoromethyl group, R 8 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl, R 9 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl, R 10 is hydrogen, methyl or fluorine and R" is amino, C 1-4 acylamino or di-substituted aminomethyleneamino provided that, at most, only two of R 7 ―R 10 are other than hydrogen and that R 7 ―R 10 are not all hydrogen when R 6 is chlorine. Also provided are pharmaceutical compositions containing compounds of the formula (III), the first medical use of compounds of the formula (III), a process for preparing such compounds and intermediates through which this process proceeds.-
3.发明授权3,5-Diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them 失效3,5-二氨基-1,2,4-三嗪衍生物，制备这些化合物的方法和含有它们的药物组合物
公开(公告)号：EP0021120B1
公开(公告)日：1983-04-06
申请号：EP80103031.3
申请日：1980-05-30
发明人： Baxter, Martin George , Elphick, Albert Reginald , Miller, Alistair Ainslie , Sawyer, David Alan
IPC分类号： C07D253/06 , A61K31/53
CPC分类号： C07D253/075
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公开(公告)号：EP0059987A1
公开(公告)日：1982-09-15
申请号：EP82102293.6
申请日：1980-05-30
发明人： Baxter, Martin George , Elphick, Albert Reginald , Miller, Alistair Ainslie , Sawyer, David Alan
IPC分类号： C07C133/12
CPC分类号： C07D253/075 , C07C51/15 , C07C51/363 , C07C255/00 , C07C281/18 , C07C63/70
摘要： The present invention provides compounds of the formula (I)
wherein R 6 is chlorine, bromine, iodine, C 1-4 alkyl or trifluoromethyl; R 7 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl or R 6 and R 7 form a -CH= CH -CH=CH- group optionally substituted by a halogen atom or a C 1-4 alkyl or trifluoromethyl group; R 8 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl; R 9 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl, and R 10 is hydrogen, methyl or fluorine, provided that at most only two of R 7 -R 10 are other than hydrogen and that R 7 -R 10 are not all hydrogen when R 6 is chlorine, which are useful as intermediates for the preparation of compounds of formula (II)
wherein R 6 , R 7 , R e , R 9 and R 10 are as defined in claim 1 and R" is amino, C 1-4 acylamino or di-substituted aminomethyleneamino, being useful in the treatment of CNS disorders such epilepsy.摘要翻译： 本发明提供式（I）的化合物
其中R 6是氯，溴，碘，C 1-4烷基或三氟甲基; R 7是氢，卤素，C 1-4烷基或三氟甲基或R 6和R 7形成任选被卤素原子或C 1-4烷基取代的-CH = CH-CH = CH-基团或 三氟甲基 R 8是氢，卤素，C 1-4烷基或三氟甲基; R 9是氢，卤素，C 1-4烷基或三氟甲基，R 1是氢，甲基或氟，条件是R 7 -R 1至少只有两个 不是氢，当R 6是氯时R 7 -R 1不全是氢，它们可用作制备式（II）化合物的中间体 其中R R 6，R 7，R 8，R 9和R 1如权利要求1中所定义，R 1是氨基，C 1-4酰氨基或二 - 取代的氨基亚甲基氨基，可用于治疗中枢神经系统疾病如癫痫。 -
5.发明授权1,2,4-Triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them 失效1,2,4-三唑衍生物，制备这些化合物的方法和含有它们的药物组合物
公开(公告)号：EP0021121B1
公开(公告)日：1983-05-11
申请号：EP80103032.1
申请日：1980-05-30
发明人： Baxter, Martin George , Elphick, Albert Reginald , Miller, Alistair Ainslie , Sawyer, David Alan
IPC分类号： C07D253/06 , A61K31/53
CPC分类号： C07D253/075 , C07C51/15 , C07C51/363 , C07C255/00 , C07C281/18 , C07C63/70
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6.发明公开3,5-Diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them 失效3,5-二氨基-1,2,4-三嗪衍生物，用于制备这些化合物和含有它们的药物组合物。
公开(公告)号：EP0021120A1
公开(公告)日：1981-01-07
申请号：EP80103031.3
申请日：1980-05-30
发明人： Baxter, Martin George , Elphick, Albert Reginald , Miller, Alistair Ainslie , Sawyer, David Alan
IPC分类号： C07D253/06 , A61K31/53
CPC分类号： C07D253/075
摘要： The present invention provides compounds of the formula (III):
or an acid addition salt thereof, wherein R 6 , R 7 , R 9 and R 10 are each hydrogen, halogen, C 1-4 alkyl or trifluoromethyl and R 8 is chlorine or R 7 and R 8 ar linked to form a -CH=CH-CH=CH- group when one of R 6 and R 10 is other than hydrogen provided that when R 8 is chlorine R 6 , R 7 , R 9 and R 10 are not all hydrogen atoms and that any one of R 6 , R 7 , R 9 and R 10 is not chlorine when the other three groups are hydrogen. Also provided are pharmaceutical compositions containing compounds of the formula (III), the first medical use of compounds of the formula (III), a process for preparing such compounds and intermediates through which this process proceeds.
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