发明公开
EP0027260A2 Peptides, processes for their preparation and pharmaceutical compositions containing them
失效
肽，其制备方法以及含有它们的药物组合物的过程。
- 专利标题： Peptides, processes for their preparation and pharmaceutical compositions containing them
- 专利标题（中）： 肽，其制备方法以及含有它们的药物组合物的过程。
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申请号： EP80106143.3申请日： 1980-10-09
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公开(公告)号： EP0027260A2公开(公告)日： 1981-04-22
- 发明人: Kitaura, Yoshihiko , Nakaguchi, Osamu , Hemmi, Keiji , Aratani, Matsuhiko , Takeno, Hidekazu , Okada, Satoshi , Tanaka, Hirokazu , Hashimoto, Masashi
- 申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
- 申请人地址： 3, Doshomachi 4-chome Higashi-ku Osaka-shi Osaka 541 JP
- 专利权人： FUJISAWA PHARMACEUTICAL CO., LTD.
- 当前专利权人： FUJISAWA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 3, Doshomachi 4-chome Higashi-ku Osaka-shi Osaka 541 JP
- 代理机构： Türk, Dietmar, Dr. rer. nat.
- 优先权： GB7935401 19791011; GB7935730 19791015; GB7936000 19791017; GB8010459 19800328
- 主分类号： C07K5/00
- IPC分类号： C07K5/00 ; A61K37/02
摘要：
A compound of the formula or its pharmaceutically acceptable salt:
wherein R 1 is hydrogen or acyl;
R 2 is carboxy or protected carboxy or a group of the formula:
-COHN-R 2 wherein R 2 a is carboxy(lower)alkyl or protected carboxy(lower)alkyl;
R 3 is carboxy, protected carboxy, lower alkyl, hydroxyphenyl, carbamoyl ora graup oftheformula: R 3 a-CH-R 3 b wherein R 3 a is hydrogen, amino, protected amino or a cylamino, R 3 b is carboxy or protected carboxy;
R P is carboxy, protected carboxy, carbamoyl, carboxy(lower)alkyl or protected carboxy(lower)alkyl; ℓ isaninteger0or2, m is an integer 0 to 3 and n is an integer 0 to 1, with certain provisions, and pharmaceutically acceptable salts thereof and process for their preparation, and also a pharmaceutical composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient.
wherein R 1 is hydrogen or acyl;
R 2 is carboxy or protected carboxy or a group of the formula:
-COHN-R 2 wherein R 2 a is carboxy(lower)alkyl or protected carboxy(lower)alkyl;
R 3 is carboxy, protected carboxy, lower alkyl, hydroxyphenyl, carbamoyl ora graup oftheformula: R 3 a-CH-R 3 b wherein R 3 a is hydrogen, amino, protected amino or a cylamino, R 3 b is carboxy or protected carboxy;
R P is carboxy, protected carboxy, carbamoyl, carboxy(lower)alkyl or protected carboxy(lower)alkyl; ℓ isaninteger0or2, m is an integer 0 to 3 and n is an integer 0 to 1, with certain provisions, and pharmaceutically acceptable salts thereof and process for their preparation, and also a pharmaceutical composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient.
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