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    TRANSLOCATION AND MUTANT ROS KINASE IN HUMAN NON-SMALL CELL LUNG CARCINOMA
    5.
    发明公开
    TRANSLOCATION AND MUTANT ROS KINASE IN HUMAN NON-SMALL CELL LUNG CARCINOMA 审中-公开

    公开(公告)号：EP3936621A1

    公开(公告)日：2022-01-12

    申请号：EP21177974.9

    申请日：2007-01-19

    申请人： Cell Signaling Technology, Inc.

    发明人： Possemato, Anthony ,  Guo, Ailan

    IPC分类号： C12Q1/68 ,  G01N33/50 ,  C12N15/00 ,  C07K5/00 ,  C07H21/02

    摘要： In accordance with the invention, a novel gene translocation, (4p15, 6q22), in human non-small cell lung carcinoma (NSCLC) that results in a fusion proteins combining part of Sodium-dependent Phosphate Transporter lsoform NaPi-3b protein (SLC34A2) with Proto-oncogene Tyrosine Protein Kinase ROS Precursor (ROS) kinase has now been identified. The SLC34A2-ROS fusion protein is anticipated to drive the proliferation and survival of a subgroup of NSCLC tumors. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant ROS kinase polypeptides, probes for detecting it, isolated mutant polypeptides, recombinant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The disclosed identification of the new fusion protein enables new methods for determining the presence of these mutant ROS kinase polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides, which are also provided by the invention.

    PROTEIN DEGRADATION INDUCING TAG AND USAGE THEREOF
    6.
    发明公开
    PROTEIN DEGRADATION INDUCING TAG AND USAGE THEREOF 审中-公开

    公开(公告)号：EP3868878A2

    公开(公告)日：2021-08-25

    申请号：EP20215603.0

    申请日：2016-06-15

    申请人： Tokyo University of Science Foundation

    发明人： Miyamoto, Etsuko ,  Ozawa, Masaaki

    IPC分类号： C12N9/00 ,  A61K38/00 ,  A61P43/00 ,  C07D239/49 ,  C12Q1/02 ,  C07K5/00

    摘要： Provided is method of degrading a target protein, the method comprising the step of inducing degradation of the target protein using a protein-degradation inducing tag, wherein the protein-degradation inducing tag is a molecule having an affinity with a protease without inhibiting degradation of the protein by the protease, wherein the protein-degradation inducing tag can lead the target protein to degradation by a protease without ubiquitina-tion of the target protein and wherein the protein-degradation inducing tag has a molecular weight within the range of 50 to 5000 g/mol.