发明公开
EP0028917A2 Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances, their use and method of preparing them
失效
脂质泡囊携带Kohlehydratflächen作为用于直接治疗淋巴的治疗和诊断的化合物，它们的用途和它们的制备方法的载体。
- 专利标题： Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances, their use and method of preparing them
- 专利标题（中）： 脂质泡囊携带Kohlehydratflächen作为用于直接治疗淋巴的治疗和诊断的化合物，它们的用途和它们的制备方法的载体。
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申请号： EP80303944.5申请日： 1980-11-05
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公开(公告)号： EP0028917A2公开(公告)日： 1981-05-20
- 发明人: Baldeschwieler, John D. , Gamble, Ronald C. , Mauk, Marcia R. , Shen, Tsung-Ying , Ponpipom, Mitree M.
- 申请人： Merck & Co., Inc. , CALIFORNIA INSTITUTE OF TECHNOLOGY
- 申请人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 专利权人： Merck & Co., Inc.,CALIFORNIA INSTITUTE OF TECHNOLOGY
- 当前专利权人： Merck & Co., Inc.,CALIFORNIA INSTITUTE OF TECHNOLOGY
- 当前专利权人地址： 126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
- 代理机构： Crampton, Keith John Allen
- 优先权： US92342 19791108
- 主分类号： A61K9/50
- IPC分类号： A61K9/50
摘要：
Lipid vesicles comprise a lipid bilayer which includes an analog of a cell-surface receptor such as dicetyl phosphate, stearylamine, 6-(5-cholesten-3β-yloxy)hexyl 1-thio-β-L-fucopyranoside, 6-(5-cholesten-3β-yloxy)hexyl 1-thio-β-D-galactopyranoside, 6-(5-cholesten- 3β-yloxy)hexyl 1-thio-a- D-mannopyranoside, 6-(5-cholesten- 3-yloxy)hexyl 2-acetamido-3-deoxy- 1-thio-β-D-galactopyranoside, 6-(5-cholesten- 3β-yloxy)hexyl 6-amino-6-deoxy-1-thio- β-D-galactopyranoside or 6-(5-cholesten- 3p-yloxy)hexyl 6-amino-6-deoxy-1- thio-a-D-mannopyranoside, together with cholesterol, distearoyl phospatidylcholine and an effective amount of a physiologically compatible radioactive tracer or a cytotoxic or therapeutic agent as a part of the vesicles. The vesicles of this invention can be administered to mammalian, including human, hosts and have been found to release the contents of the vesicles in a predetermined manner, and in some cases to be rapidly concentrated in the lymphatic system and / or liver, lungs, or spleen of the host.
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