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1.发明公开Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances, their use and method of preparing them 失效作为用于治疗和诊断物质的淋巴细针型车辆的碳酸氢钠表面的脂质纤维，其使用及其制备方法
公开(公告)号：EP0028917A3
公开(公告)日：1981-07-15
申请号：EP80303944
申请日：1980-11-05
发明人： Baldeschwieler, John D. , Gamble, Ronald C. , Mauk, Marcia R. , Shen, Tsung-Ying , Ponpipom, Mitree M.
IPC分类号： A61K09/50
CPC分类号： A61K9/1272 , A61K9/127 , A61K9/1271 , Y10T428/2984
摘要： Lipid vesicles comprise a lipid bilayer which includes an analog of a cell-surface receptor such as dicetyl phosphate, stearylamine, 6-(5-cholesten-3β-yloxy)hexyl 1-thio-β-L-fucopyranoside, 6-(5-cholesten-3β-yloxy)hexyl 1-thio-β-D-galactopyranoside, 6-(5-cholesten- 3β-yloxy)hexyl 1-thio-a- D-mannopyranoside, 6-(5-cholesten- 3-yloxy)hexyl 2-acetamido-3-deoxy- 1-thio-β-D-galactopyranoside, 6-(5-cholesten- 3β-yloxy)hexyl 6-amino-6-deoxy-1-thio- β-D-galactopyranoside or 6-(5-cholesten- 3p-yloxy)hexyl 6-amino-6-deoxy-1- thio-a-D-mannopyranoside, together with cholesterol, distearoyl phospatidylcholine and an effective amount of a physiologically compatible radioactive tracer or a cytotoxic or therapeutic agent as a part of the vesicles. The vesicles of this invention can be administered to mammalian, including human, hosts and have been found to release the contents of the vesicles in a predetermined manner, and in some cases to be rapidly concentrated in the lymphatic system and / or liver, lungs, or spleen of the host.
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2.发明公开Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances, their use and method of preparing them 失效脂质泡囊携带Kohlehydratflächen作为用于直接治疗淋巴的治疗和诊断的化合物，它们的用途和它们的制备方法的载体。
公开(公告)号：EP0028917A2
公开(公告)日：1981-05-20
申请号：EP80303944.5
申请日：1980-11-05
发明人： Baldeschwieler, John D. , Gamble, Ronald C. , Mauk, Marcia R. , Shen, Tsung-Ying , Ponpipom, Mitree M.
IPC分类号： A61K9/50
CPC分类号： A61K9/1272 , A61K9/127 , A61K9/1271 , Y10T428/2984
摘要： Lipid vesicles comprise a lipid bilayer which includes an analog of a cell-surface receptor such as dicetyl phosphate, stearylamine, 6-(5-cholesten-3β-yloxy)hexyl 1-thio-β-L-fucopyranoside, 6-(5-cholesten-3β-yloxy)hexyl 1-thio-β-D-galactopyranoside, 6-(5-cholesten- 3β-yloxy)hexyl 1-thio-a- D-mannopyranoside, 6-(5-cholesten- 3-yloxy)hexyl 2-acetamido-3-deoxy- 1-thio-β-D-galactopyranoside, 6-(5-cholesten- 3β-yloxy)hexyl 6-amino-6-deoxy-1-thio- β-D-galactopyranoside or 6-(5-cholesten- 3p-yloxy)hexyl 6-amino-6-deoxy-1- thio-a-D-mannopyranoside, together with cholesterol, distearoyl phospatidylcholine and an effective amount of a physiologically compatible radioactive tracer or a cytotoxic or therapeutic agent as a part of the vesicles. The vesicles of this invention can be administered to mammalian, including human, hosts and have been found to release the contents of the vesicles in a predetermined manner, and in some cases to be rapidly concentrated in the lymphatic system and / or liver, lungs, or spleen of the host.
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3.发明授权Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances, their use and method of preparing them 失效作为用于治疗和诊断物质的淋巴指导的车辆的碳酸氢钠表面的脂肪纤维，其使用及其制备方法
公开(公告)号：EP0028917B1
公开(公告)日：1984-05-30
申请号：EP80303944.5
申请日：1980-11-05
发明人： Baldeschwieler, John D. , Gamble, Ronald C. , Mauk, Marcia R. , Shen, Tsung-Ying , Ponpipom, Mitree M.
IPC分类号： A61K9/50
CPC分类号： A61K9/1272 , A61K9/127 , A61K9/1271 , Y10T428/2984
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