发明公开
EP0046990A3 2-Halogeno-4-alkyl-4,7-dihydro-7-oxo-thieno(3,2-b)-pyridine-6-carboxylic acids, salts thereof at the carboxyl group, pharmaceutical use thereof, and intermediates thereof
失效
2-卤代-4-烷基-4,7-二氢-7-氧代 - 噻吩（3,2-B） - 吡啶-6-羧酸，其在羧基上的盐，其药物用途及其中间体
- 专利标题： 2-Halogeno-4-alkyl-4,7-dihydro-7-oxo-thieno(3,2-b)-pyridine-6-carboxylic acids, salts thereof at the carboxyl group, pharmaceutical use thereof, and intermediates thereof
- 专利标题（中）： 2-卤代-4-烷基-4,7-二氢-7-氧代 - 噻吩（3,2-B） - 吡啶-6-羧酸，其在羧基上的盐，其药物用途及其中间体
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申请号： EP81106684申请日： 1981-08-27
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公开(公告)号： EP0046990A3公开(公告)日： 1982-05-12
- 发明人: Yamabe, Shigeru , Utsumi, Isamu , Tsukamoto, Goro , Kawashima, Tsuneo , Uno, Toshio
- 申请人： KANEBO, LTD.
- 专利权人： KANEBO, LTD.
- 当前专利权人： KANEBO, LTD.
- 优先权： JP12010980 19800828
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; A61K31/435 ; C07D333/36 ; C07D333/00 ; C07D221/00
摘要：
The present invention provides a 2-halogeno-4-alkyl-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxylic acid of the general formula
wherein X represents a halogen atom and R represents a lower alkyl group, or a pharmaceutically acceptable salt thereof at the carboxyl group, and an antimicrobial agent comprising as an active ingredient the above compound. The compound is useful for protecting a warm-blooded animal from bacterial infection. The present invention also provides new intermediates for production of the compound.
wherein X represents a halogen atom and R represents a lower alkyl group, or a pharmaceutically acceptable salt thereof at the carboxyl group, and an antimicrobial agent comprising as an active ingredient the above compound. The compound is useful for protecting a warm-blooded animal from bacterial infection. The present invention also provides new intermediates for production of the compound.
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