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1.发明公开Benzimidazole derivative, process for the preparation thereof and pharmaceutical composition 失效苯并咪唑衍生物，其制备方法和药物组合物的方法。
公开(公告)号：EP0123962A2
公开(公告)日：1984-11-07
申请号：EP84103831.8
申请日：1984-04-06
申请人： KANEBO, LTD.
发明人： Iemura, Ryuichi , Kawashima, Tsuneo , Fukuda, Toshikazu , Ito, Keizo , Nose, Takashi , Tsukamoto, Goro
IPC分类号： C07D235/14 , A61K31/415
CPC分类号： C07D235/14 , Y02P20/55
摘要： Novel benzimidazole derivatives of the formula:
wherein R 1 is a lower alkyl group, a lower alkenyl group or a lower alkynyl group, R 2 is hydrogen atom, a lower alkyl group or a lower hydroxyalkyl group, and n is 2 or 3, or a pharmaceutically acceptable acid addition salt thereof, which have potent antihistaminic activity with less toxicity and hence are useful as an antihistaminics, and a process for the preparation of the compounds, and a pharmaceutical composition useful as antihistaminics containing the compound as an essential active ingredient.-
2.发明公开Novel benzimidazole derivative, process for the preparation thereof and pharmaceutical composition 失效新型苯并咪唑衍生物，其制备方法和药物组合物
公开(公告)号：EP0123962A3
公开(公告)日：1987-10-07
申请号：EP84103831
申请日：1984-04-06
申请人： KANEBO, LTD.
发明人： Iemura, Ryuichi , Kawashima, Tsuneo , Fukuda, Toshikazu , Ito, Keizo , Nose, Takashi , Tsukamoto, Goro
IPC分类号： C07D235/14 , A61K31/415
CPC分类号： C07D235/14 , Y02P20/55
摘要： Novel benzimidazole derivatives of the formula:
wherein R 1 is a lower alkyl group, a lower alkenyl group or a lower alkynyl group, R 2 is hydrogen atom, a lower alkyl group or a lower hydroxyalkyl group, and n is 2 or 3, or a pharmaceutically acceptable acid addition salt thereof, which have potent antihistaminic activity with less toxicity and hence are useful as an antihistaminics, and a process for the preparation of the compounds, and a pharmaceutical composition useful as antihistaminics containing the compound as an essential active ingredient.-
3.发明授权Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same 失效苯并咪唑衍生物，其制备方法和含有该衍生物的药物组合物
公开(公告)号：EP0079545B1
公开(公告)日：1986-05-21
申请号：EP82110215.9
申请日：1982-11-05
申请人： KANEBO, LTD.
发明人： Iemura, Ryuichi , Kawashima, Tsuneo , Fukuda, Toshikazu Kanebo Tomobuchi Danchi E-204 , Ito, Keizo Kanebo Tomobuchi Danchi A-405 , Nose, Takashi , Tsukamoto, Goro
IPC分类号： C07D235/30 , C07D403/04 , A61K31/495 , A61K31/55
CPC分类号： C07D235/24 , C07D235/30 , C07D403/04 , Y02P20/55 , Y10S514/83 , Y10S514/861 , Y10S514/914
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公开(公告)号：EP0380036B1
公开(公告)日：1994-01-12
申请号：EP90101245.0
申请日：1990-01-22
申请人： KANEBO LTD.
IPC分类号： A61K31/565 , A61K9/02 , A61K47/18
CPC分类号： A61K9/02 , A61K9/0034 , A61K31/565 , A61K47/183
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5.发明公开2-Halogeno-4-alkyl-4,7-dihydro-7-oxo-thieno(3,2-b)-pyridine-6-carboxylic acids, salts thereof at the carboxyl group, pharmaceutical use thereof, and intermediates thereof 失效2-卤代-4-烷基-4,7-二氢-7-氧代 - 噻吩（3,2-B） - 吡啶-6-羧酸，其在羧基上的盐，其药物用途及其中间体
公开(公告)号：EP0046990A3
公开(公告)日：1982-05-12
申请号：EP81106684
申请日：1981-08-27
申请人： KANEBO, LTD.
IPC分类号： C07D495/04 , A61K31/435 , C07D333/36 , C07D333/00 , C07D221/00
CPC分类号： C07D495/04 , C07D333/36
摘要： The present invention provides a 2-halogeno-4-alkyl-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxylic acid of the general formula
wherein X represents a halogen atom and R represents a lower alkyl group, or a pharmaceutically acceptable salt thereof at the carboxyl group, and an antimicrobial agent comprising as an active ingredient the above compound. The compound is useful for protecting a warm-blooded animal from bacterial infection. The present invention also provides new intermediates for production of the compound.摘要翻译： 本发明提供通式
的2-卤代-4-烷基-4,7-二氢-7-氧代噻吩并[3,2-b]吡啶-6-羧酸，其中X表示卤素原子 R表示羧基的低级烷基或其药学上可接受的盐，作为上述化合物的活性成分的抗微生物剂。 该化合物可用于保护温血动物免受细菌感染。 本发明还提供了用于生产化合物的新中间体。 -
公开(公告)号：EP0380036A2
公开(公告)日：1990-08-01
申请号：EP90101245.0
申请日：1990-01-22
申请人： KANEBO LTD.
IPC分类号： A61K31/565 , A61K9/02 , A61K47/18
CPC分类号： A61K9/02 , A61K9/0034 , A61K31/565 , A61K47/183
摘要： Disclosed is a vaginal suppository comprising a pharmaceutically acceptable salt of dehydroepiandrosterone sulfate (hereinafter referred to as DHAS), an amino acid and a hard fat having a hydroxy value of not more than 50. This suppository features an improved absorption of the active drug from the vagina plus a good shelf life.
摘要翻译： 公开了一种阴道栓剂，其包含硫酸脱氢表雄酮（以下称为DHAS）的药学上可接受的盐，羟基值不大于50的氨基酸和硬脂。该栓剂的特征在于活性药物从 阴道加好货架期。
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7.发明授权Benzimidazole derivative, process for the preparation thereof and pharmaceutical composition 失效苯并咪唑衍生物，其制备方法和药物组合物
公开(公告)号：EP0123962B1
公开(公告)日：1989-12-27
申请号：EP84103831.8
申请日：1984-04-06
申请人： KANEBO, LTD.
发明人： Iemura, Ryuichi , Kawashima, Tsuneo , Fukuda, Toshikazu , Ito, Keizo , Nose, Takashi , Tsukamoto, Goro
IPC分类号： C07D235/14 , A61K31/415
CPC分类号： C07D235/14 , Y02P20/55
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公开(公告)号：EP0380036A3
公开(公告)日：1990-12-05
申请号：EP90101245.0
申请日：1990-01-22
申请人： KANEBO LTD.
IPC分类号： A61K31/565 , A61K9/02 , A61K47/18
CPC分类号： A61K9/02 , A61K9/0034 , A61K31/565 , A61K47/183
摘要： Disclosed is a vaginal suppository comprising a pharmaceutically acceptable salt of dehydroepiandrosterone sulfate (hereinafter referred to as DHAS), an amino acid and a hard fat having a hydroxy value of not more than 50. This suppository features an improved absorption of the active drug from the vagina plus a good shelf life.
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9.发明公开Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same 失效苯并咪唑衍生物，它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0079545A1
公开(公告)日：1983-05-25
申请号：EP82110215.9
申请日：1982-11-05
申请人： KANEBO, LTD.
发明人： Iemura, Ryuichi , Kawashima, Tsuneo , Fukuda, Toshikazu Kanebo Tomobuchi Danchi E-204 , Ito, Keizo Kanebo Tomobuchi Danchi A-405 , Nose, Takashi , Tsukamoto, Goro
IPC分类号： C07D235/30 , C07D403/04 , A61K31/495 , A61K31/55
CPC分类号： C07D235/24 , C07D235/30 , C07D403/04 , Y02P20/55 , Y10S514/83 , Y10S514/861 , Y10S514/914
摘要： Novel benzimidazole derivatives of the formula:
wherein R' is an alkyl group having 1 to 3 carbon atoms, allyl group, propargyl group, or phenyl group; R 2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; and n is 2 or 3, or pharmaceutically acceptable acid addition salts thereof, which have excellent antihistaminic activities and are useful as antiallergics for various allergic diseases, and a process for the preparation thereof, and an antihistaminic composition containing the compound as an active ingredient.-
10.发明公开2-Halogeno-4-alkyl-4,7-dihydro-7-oxo-thieno(3,2-b)-pyridine-6-carboxylic acids, salts thereof at the carboxyl group, pharmaceutical use thereof, and intermediates thereof 失效2-卤代-4-烷基-4,7-二氢-7-氧代噻吩并（3,2-b）吡啶羧酸盐，德国Salze，ihre therapeutische Verwendung und Zwischenprodukte。
公开(公告)号：EP0046990A2
公开(公告)日：1982-03-10
申请号：EP81106684.4
申请日：1981-08-27
申请人： KANEBO, LTD.
IPC分类号： C07D495/04 , A61K31/435 , C07D333/36
CPC分类号： C07D495/04 , C07D333/36
摘要： The present invention provides a 2-halogeno-4-alkyl-4,7-dihydro-7-oxo-thieno[3,2-b]pyridine-6-carboxylic acid of the general formula
wherein X represents a halogen atom and R represents a lower alkyl group, or a pharmaceutically acceptable salt thereof at the carboxyl group, and an antimicrobial agent comprising as an active ingredient the above compound.
The compound is useful for protecting a warm-blooded animal from bacterial infection.
The present invention also provides new intermediates for production of the compound.摘要翻译： 本发明提供通式
的2-卤代-4-烷基-4,7-二氢-7-氧代噻吩并[3,2-b]吡啶-6-羧酸，其中X表示卤素原子 R表示羧基的低级烷基或其药学上可接受的盐，作为上述化合物的活性成分的抗微生物剂。 该化合物可用于保护温血动物免受细菌感染。 本发明还提供了用于生产化合物的新中间体。
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