发明公开
EP0048136A2 Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
失效
一种用于烷基羧酸或它们的酯的制备过程中，通过芳族基团的α-取代。
- 专利标题： Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
- 专利标题（中）： 一种用于烷基羧酸或它们的酯的制备过程中，通过芳族基团的α-取代。
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申请号： EP81304154.8申请日： 1981-09-10
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公开(公告)号： EP0048136A2公开(公告)日： 1982-03-24
- 发明人: Tsuchihashi, Genichi , Mitamura, Shuichi , Kitajima, Kouji
- 申请人： SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED
- 申请人地址： Corner House Church Street Hamilton 5 BM
- 专利权人： SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED
- 当前专利权人： SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED
- 当前专利权人地址： Corner House Church Street Hamilton 5 BM
- 代理机构： Cresswell, Thomas Anthony
- 优先权： JP125355/80 19800911; JP143042/80 19801015; JP157049/80 19801110; JP11700/81 19810130; JP90979/81 19810615
- 主分类号： C07C67/333
- IPC分类号： C07C67/333 ; C07C143/68
摘要：
A process for preparing an alpha-aromatic group substituted alkanoic acid or its ester of the general formula
wherein Ar represents an aromatic group and R' represents a hydrogen atom or a saturated aliphatic group, or Ar and R 1 may form a condensed ring together with the carbon atom to which they are bonded; and R 2 represents a hydrogen atom, an alkyl group, or a hydroxyalkyl group. characterized in that an alpha-sulfonyloxyketone acetal of the general formula
wherein R 3 and R 4 , independently from each other, represent an alkyl group, or taken together, represent an alkylene group; R 5 represents a substituted or unsubstituted alkyl group or an aromatic group; and Ar and R 1 are as defined above, is hydrolyzed, or treated with an agent having affinity for oxygen: and novel intermediate compounds of the general formula (II) used in aforesaid process.
wherein Ar represents an aromatic group and R' represents a hydrogen atom or a saturated aliphatic group, or Ar and R 1 may form a condensed ring together with the carbon atom to which they are bonded; and R 2 represents a hydrogen atom, an alkyl group, or a hydroxyalkyl group. characterized in that an alpha-sulfonyloxyketone acetal of the general formula
wherein R 3 and R 4 , independently from each other, represent an alkyl group, or taken together, represent an alkylene group; R 5 represents a substituted or unsubstituted alkyl group or an aromatic group; and Ar and R 1 are as defined above, is hydrolyzed, or treated with an agent having affinity for oxygen: and novel intermediate compounds of the general formula (II) used in aforesaid process.
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