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    Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
    1.
    发明公开
    Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof 失效
    一种用于烷基羧酸或它们的酯的制备过程中，通过芳族基团的α-取代。

    公开(公告)号：EP0048136A2

    公开(公告)日：1982-03-24

    申请号：EP81304154.8

    申请日：1981-09-10

    申请人： SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED

    发明人： Tsuchihashi, Genichi ,  Mitamura, Shuichi ,  Kitajima, Kouji

    IPC分类号： C07C67/333 ,  C07C143/68

    CPC分类号： C07D333/24 ,  C07C43/307 ,  C07C43/315 ,  C07C45/46 ,  C07C45/63 ,  C07C49/80 ,  C07C51/00 ,  C07C57/30 ,  C07C59/64 ,  C07C309/00 ,  C07D209/46 ,  C07D303/48 ,  C07D317/20 ,  C07D317/24 ,  C07D333/22 ,  C07C49/84 ,  C07C57/32 ,  C07C63/06

    摘要： A process for preparing an alpha-aromatic group substituted alkanoic acid or its ester of the general formula
    wherein Ar represents an aromatic group and R' represents a hydrogen atom or a saturated aliphatic group, or Ar and R 1 may form a condensed ring together with the carbon atom to which they are bonded; and R 2 represents a hydrogen atom, an alkyl group, or a hydroxyalkyl group. characterized in that an alpha-sulfonyloxyketone acetal of the general formula
    wherein R 3 and R 4 , independently from each other, represent an alkyl group, or taken together, represent an alkylene group; R 5 represents a substituted or unsubstituted alkyl group or an aromatic group; and Ar and R 1 are as defined above, is hydrolyzed, or treated with an agent having affinity for oxygen: and novel intermediate compounds of the general formula (II) used in aforesaid process.

    摘要翻译： 一种用于制备α-芳基substituiertem链烷酸或它的通式酯过程 worin的Ar darstellt芳族基团和R <1> darstellt一个氢原子或饱和脂肪族基团，或Ar及R <1> 可以与它们所结合的碳原子一起形成稠合环; 且R <2> darstellt的氢原子的烷基，或羟烷基，在上述通式 worin的R那样的α-磺酰氧基缩醛为特征的<3>和R <4>，从海誓山盟unabhängig， 表示到烷基。 或者一起，在亚烷基代表; [R <6> darstellt一个substituiertem奥德unsubstituiertem烷基或芳族基团; 且Ar和R <1>如上文所定义，被hydrolyred，或与具有对氧的亲和性的试剂处理; 并且在上述方法中使用的通式（II）的新的中间体化合物。