发明公开
- 专利标题: Alpha-cyano-alpha-((N-guanidino)-imino) toluenes
- 专利标题(中): α-氰基-α - ((N-胍基) - 亚氨基)甲苯。
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申请号: EP82102293.6申请日: 1980-05-30
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公开(公告)号: EP0059987A1公开(公告)日: 1982-09-15
- 发明人: Baxter, Martin George , Elphick, Albert Reginald , Miller, Alistair Ainslie , Sawyer, David Alan
- 申请人: THE WELLCOME FOUNDATION LIMITED
- 申请人地址: Unicorn House 160 Euston Road P.O. Box 129 London NW1 2BP GB
- 专利权人: THE WELLCOME FOUNDATION LIMITED
- 当前专利权人: THE WELLCOME FOUNDATION LIMITED
- 当前专利权人地址: Unicorn House 160 Euston Road P.O. Box 129 London NW1 2BP GB
- 代理机构: Sandmair, Kurt, Dr. Dr.
- 优先权: GB7919257 19790601
- 主分类号: C07C133/12
- IPC分类号: C07C133/12
摘要:
The present invention provides compounds of the formula (I)
wherein R 6 is chlorine, bromine, iodine, C 1-4 alkyl or trifluoromethyl; R 7 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl or R 6 and R 7 form a -CH= CH -CH=CH- group optionally substituted by a halogen atom or a C 1-4 alkyl or trifluoromethyl group; R 8 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl; R 9 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl, and R 10 is hydrogen, methyl or fluorine, provided that at most only two of R 7 -R 10 are other than hydrogen and that R 7 -R 10 are not all hydrogen when R 6 is chlorine, which are useful as intermediates for the preparation of compounds of formula (II)
wherein R 6 , R 7 , R e , R 9 and R 10 are as defined in claim 1 and R" is amino, C 1-4 acylamino or di-substituted aminomethyleneamino, being useful in the treatment of CNS disorders such epilepsy.
wherein R 6 is chlorine, bromine, iodine, C 1-4 alkyl or trifluoromethyl; R 7 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl or R 6 and R 7 form a -CH= CH -CH=CH- group optionally substituted by a halogen atom or a C 1-4 alkyl or trifluoromethyl group; R 8 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl; R 9 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl, and R 10 is hydrogen, methyl or fluorine, provided that at most only two of R 7 -R 10 are other than hydrogen and that R 7 -R 10 are not all hydrogen when R 6 is chlorine, which are useful as intermediates for the preparation of compounds of formula (II)
wherein R 6 , R 7 , R e , R 9 and R 10 are as defined in claim 1 and R" is amino, C 1-4 acylamino or di-substituted aminomethyleneamino, being useful in the treatment of CNS disorders such epilepsy.
公开/授权文献
- EP0059987B1 Alpha-cyano-alpha-((N-guanidino)-imino) toluenes 公开/授权日:1985-08-14
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