发明公开
EP0059987A1 Alpha-cyano-alpha-((N-guanidino)-imino) toluenes 失效
α-氰基-α - ((N-胍基) - 亚氨基)甲苯。

Alpha-cyano-alpha-((N-guanidino)-imino) toluenes
摘要:
The present invention provides compounds of the formula (I)
wherein R 6 is chlorine, bromine, iodine, C 1-4 alkyl or trifluoromethyl; R 7 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl or R 6 and R 7 form a -CH= CH -CH=CH- group optionally substituted by a halogen atom or a C 1-4 alkyl or trifluoromethyl group; R 8 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl; R 9 is hydrogen, halogen, C 1-4 alkyl or trifluoromethyl, and R 10 is hydrogen, methyl or fluorine, provided that at most only two of R 7 -R 10 are other than hydrogen and that R 7 -R 10 are not all hydrogen when R 6 is chlorine, which are useful as intermediates for the preparation of compounds of formula (II)
wherein R 6 , R 7 , R e , R 9 and R 10 are as defined in claim 1 and R" is amino, C 1-4 acylamino or di-substituted aminomethyleneamino, being useful in the treatment of CNS disorders such epilepsy.
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