发明公开
- 专利标题： Phosphorus-containing oligopeptides, processes for preparation thereof and a pharmaceutical composition containing the same
- 专利标题（中）： 含磷寡肽，它们的制备方法和在包含它们的药物组合物。
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申请号： EP82102277.9申请日： 1982-03-19
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公开(公告)号： EP0061172A1公开(公告)日： 1982-09-29
- 发明人: Kase, Hiroshi , Yamato, Masayuki , Koguchi, Toshiro , Okachi, Ryo , Kasai, Masaji , Shirahata, Kunikatsu , Kawamoto, Isao , Shuto, Katsuichi , Karasawa, Akira , Deguchi, Takashi , Nakayama, Kiyoshi
- 申请人： KYOWA HAKKO KOGYO CO., LTD.
- 申请人地址： Ohtemachi Bldg., 6-1, Ohtemachi I-chome Chiyoda-ku, Tokyo 100 JP
- 专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人： KYOWA HAKKO KOGYO CO., LTD.
- 当前专利权人地址： Ohtemachi Bldg., 6-1, Ohtemachi I-chome Chiyoda-ku, Tokyo 100 JP
- 代理机构： Casalonga, Axel
- 优先权： JP40651/81 19810320; JP128740/81 19810819; JP184198/81 19811117; JP184199/81 19811117
- 主分类号： C07F9/38
- IPC分类号： C07F9/38 ; C12P21/02 ; C12R1/03 ; C12R1/04 ; A61K37/02
摘要：
Oligopeptides that contain phosporus, represented by the formule
in which R, represents hydrogen, lower alkyl, substituted or non substituted phenyl alkyl, or R 4 CO- (where R 4 represents hydrogen, lower alkyl, or substituted or non substituted phenyl alkyl), R 2 represents lower alkyl, R 3 represents hydrogen, lower alkyl, or substituted or non substituted phenyl alkyl, and Y represents hydrogen or hydroxyl exhibiting a hypertensive activity.
These oligopeptides can be prepared either by synthetic methods or, for two of them (namely antibiotics K-4 and K26), by cultivating microorganisms belonging to the genus ACTINOMADURA SPICULOSOSPORA NOV. SP K-4 (Ferm P-6101) and ACTINOMYCES K-26 (FERM P-5889, NRRL 12379) respectively.
in which R, represents hydrogen, lower alkyl, substituted or non substituted phenyl alkyl, or R 4 CO- (where R 4 represents hydrogen, lower alkyl, or substituted or non substituted phenyl alkyl), R 2 represents lower alkyl, R 3 represents hydrogen, lower alkyl, or substituted or non substituted phenyl alkyl, and Y represents hydrogen or hydroxyl exhibiting a hypertensive activity.
These oligopeptides can be prepared either by synthetic methods or, for two of them (namely antibiotics K-4 and K26), by cultivating microorganisms belonging to the genus ACTINOMADURA SPICULOSOSPORA NOV. SP K-4 (Ferm P-6101) and ACTINOMYCES K-26 (FERM P-5889, NRRL 12379) respectively.
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