发明公开
EP0062434A1 Insoluble crosslinked cytotoxic oxidase-peroxidase system 失效
不溶性交联的细胞毒性氧化酶 - 过氧化物酶系统。

  • 专利标题: Insoluble crosslinked cytotoxic oxidase-peroxidase system
  • 专利标题(中): 不溶性交联的细胞毒性氧化酶 - 过氧化物酶系统。
  • 申请号: EP82301451.9
    申请日: 1982-03-19
  • 公开(公告)号: EP0062434A1
    公开(公告)日: 1982-10-13
  • 发明人: Kiel, Jonathan L
  • 申请人: Kiel, Jonathan L
  • 申请人地址: 5814 Fort Stanwix San Antonio Texas 78233 US
  • 专利权人: Kiel, Jonathan L
  • 当前专利权人: Kiel, Jonathan L
  • 当前专利权人地址: 5814 Fort Stanwix San Antonio Texas 78233 US
  • 代理机构: McCallum, William Potter
  • 优先权: US251694 19810407
  • 主分类号: C12N11/18
  • IPC分类号: C12N11/18 A61K37/50
Insoluble crosslinked cytotoxic oxidase-peroxidase system
摘要:
A therapeutic preparation, and a process of using the preparation, for the control of tumour growth and infectious diseases. The preparation is an immobilized cytotoxic enzyme system which is carried by an insoluble substrate that is administered into the mammalian subject by injection or implantation. The preferred embodiment of the preparation uses a polymerized albumin carrier containing immobilized glucose oxidase and peroxidase. The immobilized enzyme system is prepared in the form of small particles that can be administered either by implantation or by injection into tumour-bearing mammals. To date, antibacterial activity has been demonstrated only in vitro. Intraperitoneal injection into rats bearing Novikoff hepatomas or into mice bearing B16-Fl melanomas or L1210 (Lymphoid) tumours has resulted in the selected killing of tumour tissues. Several daily administrations are required to achieve complete destruction of the tumour. Additionally, the preparation is also active as a stimulant of the specific immune response to neoplasia. Its effect on the immune system could be useful in the stimulation of the immune system in diseases where the action of the endogenous immune system is insufficient.
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