发明公开
EP0075392A1 Process for de-cyanoethylating blocked nucleotides 失效
Verfahren zur De-cyanoethylierung von blockierten Nucleotiden。

  • 专利标题: Process for de-cyanoethylating blocked nucleotides
  • 专利标题(中): Verfahren zur De-cyanoethylierung von blockierten Nucleotiden。
  • 申请号: EP82304434.2
    申请日: 1982-08-23
  • 公开(公告)号: EP0075392A1
    公开(公告)日: 1983-03-30
  • 发明人: Hsiung, Hansen Maxwell
  • 申请人: ELI LILLY AND COMPANY
  • 申请人地址: 307, East McCarty Street Indianapolis Indiana 46285 US
  • 专利权人: ELI LILLY AND COMPANY
  • 当前专利权人: ELI LILLY AND COMPANY
  • 当前专利权人地址: 307, East McCarty Street Indianapolis Indiana 46285 US
  • 代理机构: Hudson, Christopher Mark
  • 优先权: US295420 19810824; US295421 19810824
  • 主分类号: C07H21/00
  • IPC分类号: C07H21/00
Process for de-cyanoethylating blocked nucleotides
摘要:
A process for selectively removing a β-cyanoethyl blocking group from the phosphate moiety of a nucleotide or polynucleotide, which comprises treating said nucleotide or polynucleotide with a primary amine having from 3 to 5 carbon atoms or diethylamine.
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