发明公开
- 专利标题： Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
- 专利标题（中）： 苯并咪唑衍生物，它们的制备方法和含有它们的药物组合物。
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申请号： EP82110215.9申请日： 1982-11-05
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公开(公告)号： EP0079545A1公开(公告)日： 1983-05-25
- 发明人: Iemura, Ryuichi , Kawashima, Tsuneo , Fukuda, Toshikazu Kanebo Tomobuchi Danchi E-204 , Ito, Keizo Kanebo Tomobuchi Danchi A-405 , Nose, Takashi , Tsukamoto, Goro
- 申请人： KANEBO, LTD.
- 申请人地址： 17-4 Sumida 5-chome Sumida-ku Tokyo 131 JP
- 专利权人： KANEBO, LTD.
- 当前专利权人： KANEBO, LTD.
- 当前专利权人地址： 17-4 Sumida 5-chome Sumida-ku Tokyo 131 JP
- 代理机构： Hansen, Bernd, Dr. Dipl.-Chem.
- 优先权： JP178804/81 19811106
- 主分类号： C07D235/30
- IPC分类号： C07D235/30 ; C07D403/04 ; A61K31/495 ; A61K31/55
摘要：
Novel benzimidazole derivatives of the formula:
wherein R' is an alkyl group having 1 to 3 carbon atoms, allyl group, propargyl group, or phenyl group; R 2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; and n is 2 or 3, or pharmaceutically acceptable acid addition salts thereof, which have excellent antihistaminic activities and are useful as antiallergics for various allergic diseases, and a process for the preparation thereof, and an antihistaminic composition containing the compound as an active ingredient.
wherein R' is an alkyl group having 1 to 3 carbon atoms, allyl group, propargyl group, or phenyl group; R 2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; and n is 2 or 3, or pharmaceutically acceptable acid addition salts thereof, which have excellent antihistaminic activities and are useful as antiallergics for various allergic diseases, and a process for the preparation thereof, and an antihistaminic composition containing the compound as an active ingredient.
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