发明公开
EP0101162A2 Novel 3-(2-(azabicyclo) ethyl)1,2,3,4-tetrahydro-5H(1)benzopyrano(3,4-c)pyridin-5-ones, pharmaceutical compositions containing them and processes for their production
失效
3-(2-(氮杂双环)乙基)-1,2,3,4-四氢-5H-(1)苯并吡喃(3,4-c)吡啶-5-酮,含有它们的它们的制备方法的药物组合物。
- 专利标题: Novel 3-(2-(azabicyclo) ethyl)1,2,3,4-tetrahydro-5H(1)benzopyrano(3,4-c)pyridin-5-ones, pharmaceutical compositions containing them and processes for their production
- 专利标题(中): 3-(2-(氮杂双环)乙基)-1,2,3,4-四氢-5H-(1)苯并吡喃(3,4-c)吡啶-5-酮,含有它们的它们的制备方法的药物组合物。
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申请号: EP83303557.9申请日: 1983-06-21
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公开(公告)号: EP0101162A2公开(公告)日: 1984-02-22
- 发明人: Connor, David T. , Schwender, Charles F. , Sorenson, Roderick J. , Unangst, Paul C.
- 申请人: WARNER-LAMBERT COMPANY
- 申请人地址: 201 Tabor Road Morris Plains New Jersey 07950 US
- 专利权人: WARNER-LAMBERT COMPANY
- 当前专利权人: WARNER-LAMBERT COMPANY
- 当前专利权人地址: 201 Tabor Road Morris Plains New Jersey 07950 US
- 代理机构: Jones, Michael Raymond
- 优先权: US391197 19820622
- 主分类号: C07D491/052
- IPC分类号: C07D491/052 ; C07D491/153 ; C07D519/00 ; A61K31/435 ; A61K31/55
摘要:
Anticholinergic 3-[2-(azabicyclo)ethyl)-1,2,3,4-tetra- hydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones, useful for treating broncho-spastic diseases in mammals, are disclosed. Also disclosed are methods for preparing such novel compounds, and pharmaceutical compositions containing them. The novel compounds have the formula I:
wherein R 1 is a hydrogen atom, an alkyl radical having from 1 to 6 carbon atoms, an alkoxy radical having from 1 to 6 carbon atoms, or a hydroxy, nitro, halo, amino or acylamino radical; R 2 is a hydrogen atom, a hydroxy radical, an alkyl radical having from 1 to 6 carbon atoms, an alkoxy radical having from 1 to 6 carbon atoms or a phenyl radical; R 3 is a hydrogen atom or an alkoxy radical having from 1 to 6 carbon atoms; or R 1 and R 2 taken together are -OCH 2 0-; or R 2 and R 3 taken together are -CH=CH-CH=CH-; and
or a pharmaceutically acceptable salt thereof, provided that R 1 is not hydroxy when R 2 is -OC 2 H 5 and X is
wherein R 1 is a hydrogen atom, an alkyl radical having from 1 to 6 carbon atoms, an alkoxy radical having from 1 to 6 carbon atoms, or a hydroxy, nitro, halo, amino or acylamino radical; R 2 is a hydrogen atom, a hydroxy radical, an alkyl radical having from 1 to 6 carbon atoms, an alkoxy radical having from 1 to 6 carbon atoms or a phenyl radical; R 3 is a hydrogen atom or an alkoxy radical having from 1 to 6 carbon atoms; or R 1 and R 2 taken together are -OCH 2 0-; or R 2 and R 3 taken together are -CH=CH-CH=CH-; and
or a pharmaceutically acceptable salt thereof, provided that R 1 is not hydroxy when R 2 is -OC 2 H 5 and X is
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