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18 条记录 (耗时 0.011 秒)

    8-Substituted guanine derivatives
    4.
    发明公开
    8-Substituted guanine derivatives 失效
    8取代的产品衍生物

    公开(公告)号：EP0156559A3

    公开(公告)日：1986-10-08

    申请号：EP85301561

    申请日：1985-03-07

    申请人： WARNER-LAMBERT COMPANY

    发明人： Sircar, Jagadish C. ,  Brungardt, Catherine R. ,  Schwender, Charles F.

    IPC分类号： C07D473/18 ,  C07D473/24 ,  C07D473/40 ,  A61K31/52

    CPC分类号： C07D473/00

    摘要： Compounds of formula
    and their pharmaceutically acceptable salts are disclosed. R 1 is 0 or S; R 2 is bromine or NHR where R is hydrogen or COR 5 where R s is alkyl of 1-4 carbon atoms, aryl or arylalkyl; and X and Y are each independently halogen, alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, trifluoromethyl, hydroxy, CN, SO n R 3 , COOR 3 , NR 3 R 4 , in which R 3 and R 4 are each independently hydrogen or alkyl of 1-4 carbon atoms and n is 0, 1, 2 or 3, and Y is further chosen from hydrogen. Also disclosed are a process for producing the compounds and pharmaceutical compounds comprising the compounds. The compounds are useful for treating autoimmune diseases.

    8-Substituted guanine derivatives
    8.
    发明公开
    8-Substituted guanine derivatives 失效
    8-取代的鸟嘌呤衍生物

    公开(公告)号：EP0156559A2

    公开(公告)日：1985-10-02

    申请号：EP85301561.8

    申请日：1985-03-07

    申请人： WARNER-LAMBERT COMPANY

    发明人： Sircar, Jagadish C. ,  Brungardt, Catherine R. ,  Schwender, Charles F.

    IPC分类号： C07D473/18 ,  C07D473/24

    CPC分类号： C07D473/00

    摘要： Compounds of formula
    and their pharmaceutically acceptable salts are disclosed. R 1 is 0 or S; R 2 is bromine or NHR where R is hydrogen or COR 5 where R s is alkyl of 1-4 carbon atoms, aryl or arylalkyl; and X and Y are each independently halogen, alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, trifluoromethyl, hydroxy, CN, SO n R 3 , COOR 3 , NR 3 R 4 , in which R 3 and R 4 are each independently hydrogen or alkyl of 1-4 carbon atoms and n is 0, 1, 2 or 3, and Y is further chosen from hydrogen. Also disclosed are a process for producing the compounds and pharmaceutical compounds comprising the compounds. The compounds are useful for treating autoimmune diseases.

    摘要翻译： 公开了式的化合物及其药学上可接受的盐。 R1是0或S; R2是溴或NHR，其中R是氢或COR5，其中R5是1-4个碳原子的烷基，芳基或芳基烷基; 并且X和Y各自独立地为卤素，1-4个碳原子的烷基，1-4个碳原子的烷氧基，三氟甲基，羟基，CN，SOnR3，COOR3，NR3R4，其中R3和R4各自独立地为氢或1的烷基 -4碳原子且n是0,1,2或3，并且Y进一步选自氢。 还公开了生产包含所述化合物的化合物和药物化合物的方法。 该化合物可用于治疗自身免疫性疾病。