发明公开
EP0102226A1 Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibacterial agents
失效
4,5-二（羟甲基）-2-氧代-1,3-二氧杂环戊烯 - 双 - 酯作为抗菌药。
- 专利标题： Bis-esters of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole as antibacterial agents
- 专利标题（中）： 4,5-二（羟甲基）-2-氧代-1,3-二氧杂环戊烯 - 双 - 酯作为抗菌药。
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申请号： EP83304801.0申请日： 1983-08-19
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公开(公告)号： EP0102226A1公开(公告)日： 1984-03-07
- 发明人: Welch, Willard McKowan
- 申请人： PFIZER INC.
- 申请人地址： 235 East 42nd Street New York, N.Y. 10017 US
- 专利权人： PFIZER INC.
- 当前专利权人： PFIZER INC.
- 当前专利权人地址： 235 East 42nd Street New York, N.Y. 10017 US
- 代理机构： Graham, Philip Colin Christison
- 优先权： US410762 19820823; US441980 19821115
- 主分类号： C07D519/00
- IPC分类号： C07D519/00 ; C07D499/32 ; A61K31/43
摘要：
Derivatives of 4,5-di(hydroxymethyl)-2-oxo-1,3-dioxole in which one hydroxy group has been esterified through the carboxy group of ampicillin or amoxicillin, and the other hydroxy group has been esterified through the carboxy group of sulbactam (penicillanic acid 1,1-dioxide), are useful as antibacterial agents. Certain novel compounds, which are useful as intermediates to the aforesaid antibacterial agents, are also disclosed.
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