发明公开
EP0111994A1 (1-Arylcyclobutyl) alkylamine derivatives, their preparation and their use as therapeutic agents
失效
1-(芳基 - 环丁基 - )烷基胺衍生物,Herstellung und ihre Verwendung als Arzneimittel。
- 专利标题: (1-Arylcyclobutyl) alkylamine derivatives, their preparation and their use as therapeutic agents
- 专利标题(中): 1-(芳基 - 环丁基 - )烷基胺衍生物,Herstellung und ihre Verwendung als Arzneimittel。
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申请号: EP83305782.1申请日: 1983-09-27
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公开(公告)号: EP0111994A1公开(公告)日: 1984-06-27
- 发明人: Kozlik, Antonin , Wells, Wilfred Hase
- 申请人: The Boots Company PLC
- 申请人地址: 1 Thane Road West Nottingham, Nottinghamshire NG2 3AA GB
- 专利权人: The Boots Company PLC
- 当前专利权人: The Boots Company PLC
- 当前专利权人地址: 1 Thane Road West Nottingham, Nottinghamshire NG2 3AA GB
- 代理机构: Thacker, Michael Anthony
- 优先权: GB8227898 19820930; GB8227901 19820930
- 主分类号: C07C87/455
- IPC分类号: C07C87/455 ; C07D333/20 ; C07D307/52 ; C07D307/14 ; C07D213/38 ; C07D295/12 ; C07D233/54 ; C07D207/12 ; C07D249/08 ; C07D409/12 ; C07D401/12
摘要:
Compounds of formula I
in which n = 0 or 1;
in which, when n = 0, R 1 is H, an alkyl, a cycloalkyl, a cycloalkylmethyl, an alkenyl or, an alkynyl group a heterocyclic ring or an optionally substituted phenyl ring or when n = 1, R 1 is H or an alkyl group;
in which R 2 and R 3 are H or an alkyl group;
in which A is a group of formula III
in which W is an oxygen atom or a group of formula -S(O) m -, a group of formula -CR 12 R 13 -, a cycloalkylidene group or a cycloalkylene group; x is 0 or an integer from 1 to 5; y is 0 or an integer from 1 to 5.
in which R 4 is a carbocyclic ring, a heterocyclic ring, a cyano group, a carbamoyl group, an alkoxycarbonyl group, an amido group, an acyloxy group, a hydroxy group, a thiol group, or a group of formula -OR 20 , -SR 20 , -SOR 20 or SO 2 R 20 .
in which R 5 , R 6 and R 7 are H, halo, trifluoromethyl, hydroxy, an alkyl group, an alkoxy or alkylthio group, phenyl or R 5 and R 6 , together with the carbon atoms to which they are attached, form an optionally substituted second benzene ring;
in which R 8 and R 9 are H or an alkyl group containing 1 to 3 carbon atoms;
and pharmaceutically acceptable salts thereof have utility in the treatment of depression. Processes for their preparation and compositions containing them are disclosed.
in which n = 0 or 1;
in which, when n = 0, R 1 is H, an alkyl, a cycloalkyl, a cycloalkylmethyl, an alkenyl or, an alkynyl group a heterocyclic ring or an optionally substituted phenyl ring or when n = 1, R 1 is H or an alkyl group;
in which R 2 and R 3 are H or an alkyl group;
in which A is a group of formula III
in which W is an oxygen atom or a group of formula -S(O) m -, a group of formula -CR 12 R 13 -, a cycloalkylidene group or a cycloalkylene group; x is 0 or an integer from 1 to 5; y is 0 or an integer from 1 to 5.
in which R 4 is a carbocyclic ring, a heterocyclic ring, a cyano group, a carbamoyl group, an alkoxycarbonyl group, an amido group, an acyloxy group, a hydroxy group, a thiol group, or a group of formula -OR 20 , -SR 20 , -SOR 20 or SO 2 R 20 .
in which R 5 , R 6 and R 7 are H, halo, trifluoromethyl, hydroxy, an alkyl group, an alkoxy or alkylthio group, phenyl or R 5 and R 6 , together with the carbon atoms to which they are attached, form an optionally substituted second benzene ring;
in which R 8 and R 9 are H or an alkyl group containing 1 to 3 carbon atoms;
and pharmaceutically acceptable salts thereof have utility in the treatment of depression. Processes for their preparation and compositions containing them are disclosed.
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