发明公开
EP0111994A1 (1-Arylcyclobutyl) alkylamine derivatives, their preparation and their use as therapeutic agents 失效
1-(芳基 - 环丁基 - )烷基胺衍生物,Herstellung und ihre Verwendung als Arzneimittel。

(1-Arylcyclobutyl) alkylamine derivatives, their preparation and their use as therapeutic agents
摘要:
Compounds of formula I


in which n = 0 or 1;
in which, when n = 0, R 1 is H, an alkyl, a cycloalkyl, a cycloalkylmethyl, an alkenyl or, an alkynyl group a heterocyclic ring or an optionally substituted phenyl ring or when n = 1, R 1 is H or an alkyl group;
in which R 2 and R 3 are H or an alkyl group;
in which A is a group of formula III

in which W is an oxygen atom or a group of formula -S(O) m -, a group of formula -CR 12 R 13 -, a cycloalkylidene group or a cycloalkylene group; x is 0 or an integer from 1 to 5; y is 0 or an integer from 1 to 5.
in which R 4 is a carbocyclic ring, a heterocyclic ring, a cyano group, a carbamoyl group, an alkoxycarbonyl group, an amido group, an acyloxy group, a hydroxy group, a thiol group, or a group of formula -OR 20 , -SR 20 , -SOR 20 or SO 2 R 20 .
in which R 5 , R 6 and R 7 are H, halo, trifluoromethyl, hydroxy, an alkyl group, an alkoxy or alkylthio group, phenyl or R 5 and R 6 , together with the carbon atoms to which they are attached, form an optionally substituted second benzene ring;
in which R 8 and R 9 are H or an alkyl group containing 1 to 3 carbon atoms;
and pharmaceutically acceptable salts thereof have utility in the treatment of depression. Processes for their preparation and compositions containing them are disclosed.
信息查询
0/0