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    (1-Arylcyclobutyl) alkylamine derivatives, their preparation and their use as therapeutic agents
    1.
    发明公开
    (1-Arylcyclobutyl) alkylamine derivatives, their preparation and their use as therapeutic agents 失效
    1-（芳基 - 环丁基 - ）烷基胺衍生物，Herstellung und ihre Verwendung als Arzneimittel。

    公开(公告)号：EP0111994A1

    公开(公告)日：1984-06-27

    申请号：EP83305782.1

    申请日：1983-09-27

    申请人： The Boots Company PLC

    发明人： Kozlik, Antonin ,  Wells, Wilfred Hase

    IPC分类号： C07C87/455 ,  C07D333/20 ,  C07D307/52 ,  C07D307/14 ,  C07D213/38 ,  C07D295/12 ,  C07D233/54 ,  C07D207/12 ,  C07D249/08 ,  C07D409/12 ,  C07D401/12

    CPC分类号： C07D231/12 ,  C07C255/00 ,  C07D207/09 ,  C07D207/12 ,  C07D213/38 ,  C07D233/56 ,  C07D233/64 ,  C07D249/08 ,  C07D257/04 ,  C07D277/28 ,  C07D295/13 ,  C07D295/15 ,  C07D307/14 ,  C07D307/52 ,  C07D333/20 ,  C07D333/22 ,  C07D339/08 ,  C07D401/12 ,  C07D409/12

    摘要： Compounds of formula I


    in which n = 0 or 1;
    in which, when n = 0, R 1 is H, an alkyl, a cycloalkyl, a cycloalkylmethyl, an alkenyl or, an alkynyl group a heterocyclic ring or an optionally substituted phenyl ring or when n = 1, R 1 is H or an alkyl group;
    in which R 2 and R 3 are H or an alkyl group;
    in which A is a group of formula III

    in which W is an oxygen atom or a group of formula -S(O) m -, a group of formula -CR 12 R 13 -, a cycloalkylidene group or a cycloalkylene group; x is 0 or an integer from 1 to 5; y is 0 or an integer from 1 to 5.
    in which R 4 is a carbocyclic ring, a heterocyclic ring, a cyano group, a carbamoyl group, an alkoxycarbonyl group, an amido group, an acyloxy group, a hydroxy group, a thiol group, or a group of formula -OR 20 , -SR 20 , -SOR 20 or SO 2 R 20 .
    in which R 5 , R 6 and R 7 are H, halo, trifluoromethyl, hydroxy, an alkyl group, an alkoxy or alkylthio group, phenyl or R 5 and R 6 , together with the carbon atoms to which they are attached, form an optionally substituted second benzene ring;
    in which R 8 and R 9 are H or an alkyl group containing 1 to 3 carbon atoms;
    and pharmaceutically acceptable salts thereof have utility in the treatment of depression. Processes for their preparation and compositions containing them are disclosed.

    摘要翻译： 其中，当n = 0时，R 1为H，烷基，环烷基，环烷基甲基，烯基或炔基，杂环或杂环，其中n = 0或1; 任选取代的苯基基团，或当n = 1时，R 1，R 1为H或烷基;其中R 2和R 3和H或烷基;其中A为式III ... - （CH 2）x W- （CH 2）y-III，其中W是氧原子或式-S（O）m - ，式-CR 12 R 13 - ，亚环烷基或亚环烷基的基团，x是0或从 1至5; y为0或1〜5的整数。其中R4为碳环，杂环，氰基，氨基甲酰基，烷氧基羰基，酰胺基，酰氧基，羟基，硫醇 基团或式-OR 20，-SR 20，-SOR 20或SO 2 R 20的基团，其中R 5，R 6和R 7和H，卤素，三氟甲基，羟基，烷基，烷氧基或烷硫基，苯基或R 5和R 6 与其连接的碳原子一起形成任选取代的第二苯环;其中R 8和R 9和H或含有1至3个碳原子的烷基;及其药学上可接受的盐可用于治疗 的抑郁症 公开了其制备方法和含有它们的组合物。