发明公开
- 专利标题: Fused heterocyclic compounds
- 专利标题(中): Kondensierte heterzyklische Verbindungen。
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申请号: EP84301026.5申请日: 1984-02-17
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公开(公告)号: EP0120585A1公开(公告)日: 1984-10-03
- 发明人: Schiehser, Guy Alan , Strike, Donald Peter
- 申请人: AMERICAN HOME PRODUCTS CORPORATION
- 申请人地址: Five Giralda Farms Madison, New Jersey 07940-0874 US
- 专利权人: AMERICAN HOME PRODUCTS CORPORATION
- 当前专利权人: AMERICAN HOME PRODUCTS CORPORATION
- 当前专利权人地址: Five Giralda Farms Madison, New Jersey 07940-0874 US
- 代理机构: Wileman, David Francis
- 优先权: US468221 19830222; GB8311653 19830428
- 主分类号: C07D513/04
- IPC分类号: C07D513/04 ; A61K31/425 ; A61K31/445
摘要:
The invention concerns compounds of the formula
wherein B is a moiety having the formula:
the dotted line represents a bond which is present when B is formula Id or If and absent when B isformula le, R is hydrogen, mono- or dihalo, amino, nitro, cyano, hydroxy, trifluoromethyl, mercapto, lower alkyl, lower alkoxy, alkanoyl, lowercycloalkyl, carboxy, alkoxycarbonyl, mono- or di-lower alkyl substituted amino, alkamoylamino, lower alkyl thio, loweralkyl-sulfonyl, sulfamoyl, lower alkyl substituted sulfamoyl, phenyl or phenyl substituted with halo, lower alkyl, lower alkoxy,trifluoromethyl, hydroxy, amino, cyano or nitro; X is SO 2 , SO, S or C=O and A is an amine of formula:
wherein n is 1 to 4; R' is hydrogen or R 2 CH2 wherein R 2 is mono- or diloweralkylamino, mono- or di-N-lower- alkylamino lower alkyl, (2-furyl)methylamino, benzylamino, lower cycloalkylamino of 5 to 7 carbon atoms, 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 1-octahydroazocinyl, 3-thiazolidinyl,4-morpholinyl or4-thiomorpholinyl; R 3 is hydrogen or (1-piperidinyl)-methyl with the proviso that when R 3 is (1-piperidinyl)-methyl, then R' is hydrogen; and the pharmacologically acceptable salts thereof which inhibit gastic acid secretion. Processes for preparing the compounds and pharmaceutical compositions containing them are also disclosed.
wherein B is a moiety having the formula:
the dotted line represents a bond which is present when B is formula Id or If and absent when B isformula le, R is hydrogen, mono- or dihalo, amino, nitro, cyano, hydroxy, trifluoromethyl, mercapto, lower alkyl, lower alkoxy, alkanoyl, lowercycloalkyl, carboxy, alkoxycarbonyl, mono- or di-lower alkyl substituted amino, alkamoylamino, lower alkyl thio, loweralkyl-sulfonyl, sulfamoyl, lower alkyl substituted sulfamoyl, phenyl or phenyl substituted with halo, lower alkyl, lower alkoxy,trifluoromethyl, hydroxy, amino, cyano or nitro; X is SO 2 , SO, S or C=O and A is an amine of formula:
wherein n is 1 to 4; R' is hydrogen or R 2 CH2 wherein R 2 is mono- or diloweralkylamino, mono- or di-N-lower- alkylamino lower alkyl, (2-furyl)methylamino, benzylamino, lower cycloalkylamino of 5 to 7 carbon atoms, 1-pyrrolidinyl, 1-piperidinyl, 1-hexahydroazepinyl, 1-octahydroazocinyl, 3-thiazolidinyl,4-morpholinyl or4-thiomorpholinyl; R 3 is hydrogen or (1-piperidinyl)-methyl with the proviso that when R 3 is (1-piperidinyl)-methyl, then R' is hydrogen; and the pharmacologically acceptable salts thereof which inhibit gastic acid secretion. Processes for preparing the compounds and pharmaceutical compositions containing them are also disclosed.
公开/授权文献
- EP0120585B1 Fused heterocyclic compounds 公开/授权日:1987-12-16
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