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    PHARMACEUTICAL COMPOSITIONS OF ESTROGENIC AGENTS
    1.
    发明授权
    PHARMACEUTICAL COMPOSITIONS OF ESTROGENIC AGENTS 有权
    环境雌激素培养基中的药物组合物

    公开(公告)号：EP1309327B1

    公开(公告)日：2009-12-30

    申请号：EP01950781.3

    申请日：2001-06-29

    申请人： Wyeth

    发明人： BENJAMIN, Eric, Joel ,  DULIN, Wendy, Ann ,  SURYAWANSHI, Jiwaji, Gulabrao

    IPC分类号： A61K31/404 ,  A61K9/20

    CPC分类号： A61K31/404 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  A61K47/12

    摘要： This invention comprises novel pharmaceutical carrier or excipient systems and oral pharmaceutical formulations comprising as an active ingredient raloxifene, amoxifen, droloxifene, arzoxifene, or CP 336156, or analogs thereof, or a compound of formulae (I) or (II), wherein Z is a moiety selected from the group of formulae (a, b or c), wherein: R1 is selected from H, OH or the C1-C12 esters alkyl ethers thereof, benzyloxy, or halogen; or C1-C4 halogenated ethers; R2, R3, R4, R5, and R6 are H, OH or C1-C12 esters or alkyl ethers thereof, halogens, or C1-C4 halogenated ethers, cyano, C1-C6 alkyl, or CF3, with the proviso that, when R1 is H, R2 is not OH; Y is the moiety:formulae (d), wherein R7 and R8 are alkyl or concatenated together to form an optionally substituted, nitrogen-containing ring; or a pharmaceutically acceptable salt thereof; and excipients chosen from pharmaceutical fillers, glidants, lubricants, wetting agents and antioxidants.

    SELECTION OF POULTRY EIMERIA STRAINS THROUGH EXTRA-INTESTINAL SPOROZOITES
    6.
    发明授权
    SELECTION OF POULTRY EIMERIA STRAINS THROUGH EXTRA-INTESTINAL SPOROZOITES 有权
    EIMERIASTÄMMEN在家禽关于肠外孢子SELECTION

    公开(公告)号：EP1476558B1

    公开(公告)日：2008-08-20

    申请号：EP03713628.0

    申请日：2003-02-21

    申请人： Wyeth

    发明人： DAVELAAR, Frans, Gerrit

    IPC分类号： A61K39/012 ,  C12N1/36

    CPC分类号： C12N1/36 ,  A61K39/012 ,  A61K2039/522

    摘要： A method for obtaining an immunogenic strain useful for producing a vaccine against Coccidiosis comprises the cycle of infecting at least one first group of specific pathogen-free donor birds with oocysts from an Eimeria species. Blood is then collected from these donor birds, and is then used to infect a second group of specific pathogen-free birds. Oocysts are collected from the second group of birds. These oocysts are then multiplied to complete the cycle. The cycle is then repeated using the multiplied oocysts. After a total of about three cycles, a final immunogen may be harvested and utilized as a source to generate a vaccine against Coccidiosis.

    DERIVATIVES OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ALKYL]PHOSPHONIC ACID AND METHOD OF MAKING THEM
    9.
    发明公开
    DERIVATIVES OF [2-(8,9-DIOXO-2,6-DIAZABICYCLO[5.2.0]NON-1(7)-EN-2-YL)ALKYL]PHOSPHONIC ACID AND METHOD OF MAKING THEM 有权
    导数的[2-（8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1（7） - 烯-2-基）烷基]用于制造膦AND METHOD

    公开(公告)号：EP1797104A1

    公开(公告)日：2007-06-20

    申请号：EP05803939.7

    申请日：2005-10-06

    申请人： Wyeth

    发明人： BAUDY, Reinhardt, Richard

    IPC分类号： C07F9/645 ,  A61K31/675 ,  A61P25/02

    CPC分类号： A61K31/551 ,  C07F9/645

    摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided (Formula I): wherein: A is alkylenyl of 1 to 4 carbon atoms, or alkenylenyl of 2 to 4 carbon atoms; R1 and R2 are, independently, hydrogen or a C5 to C7 aryl optionally substituted with 1 to 2 substituents, independently, selected from the group consisting of -C(O)R3, halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy, with the proviso that at least one of R1, and R2 is not hydrogen; R3 is, independently, hydrogen, -OR4, alkyl, aryl, or heteroaryl; R4 is hydrogen, alkyl, aryl, or heteroaryl; R5 and R6 are, independently, hydrogen, alkyl, hydroxyl, alkoxy, or C5 to C7 aryl; wherein any R3 to R6 group having an aryl or heteroaryl moiety can optionally be substituted on the aryl or heteroaryl moiety with 1 to about 5 substituents, independently, selected from the group consisting of halogen, cyano, nitro, hydroxyl, C1-C6 alkyl, and C1-C6 alkoxy. Methods of making these compounds as well as methods using the compounds for treating a variety of conditions are also disclosed.