发明公开
- 专利标题： Novel benzimidazole derivative, process for the preparation thereof and pharmaceutical composition
- 专利标题（中）： 新型苯并咪唑衍生物，其制备方法和药物组合物
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申请号： EP84103831申请日： 1984-04-06
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公开(公告)号： EP0123962A3公开(公告)日： 1987-10-07
- 发明人: Iemura, Ryuichi , Kawashima, Tsuneo , Fukuda, Toshikazu , Ito, Keizo , Nose, Takashi , Tsukamoto, Goro
- 申请人： KANEBO, LTD.
- 专利权人： KANEBO, LTD.
- 当前专利权人： KANEBO, LTD.
- 优先权： JP7517883 19830427
- 主分类号： C07D235/14
- IPC分类号： C07D235/14 ; A61K31/415
摘要：
Novel benzimidazole derivatives of the formula:
wherein R 1 is a lower alkyl group, a lower alkenyl group or a lower alkynyl group, R 2 is hydrogen atom, a lower alkyl group or a lower hydroxyalkyl group, and n is 2 or 3, or a pharmaceutically acceptable acid addition salt thereof, which have potent antihistaminic activity with less toxicity and hence are useful as an antihistaminics, and a process for the preparation of the compounds, and a pharmaceutical composition useful as antihistaminics containing the compound as an essential active ingredient.
wherein R 1 is a lower alkyl group, a lower alkenyl group or a lower alkynyl group, R 2 is hydrogen atom, a lower alkyl group or a lower hydroxyalkyl group, and n is 2 or 3, or a pharmaceutically acceptable acid addition salt thereof, which have potent antihistaminic activity with less toxicity and hence are useful as an antihistaminics, and a process for the preparation of the compounds, and a pharmaceutical composition useful as antihistaminics containing the compound as an essential active ingredient.
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