发明公开
- 专利标题： Purification and characterization of a fibroblast growth factor
- 专利标题（中）： 纤维素生长因子的纯化和表征
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申请号： EP84106375申请日： 1984-06-05
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公开(公告)号： EP0131150A3公开(公告)日： 1987-07-15
- 发明人: Thomas, Kenneth A., Jr.
- 申请人： MERCK & CO. INC.
- 专利权人： MERCK & CO. INC.
- 当前专利权人： MERCK & CO. INC.
- 优先权： US505553 19830617
- 主分类号： C07K15/06
- IPC分类号： C07K15/06 ; A61K37/02 ; A61K35/30
摘要：
@ Acidic brain fibroblast growth factor isolated from bovine brain, is purified by the sequence of steps of:
1) extraction and differential salt precipitation from the source tissue; 2) ion exchange; 3) gel filtration; 4) ion exchange; 5) isoelectric focusing; 6) hydrophobic reverse phase chromatography. The product is useful in the promotion of cell division (mitogenesis) such as in the promotion of wound healing.
1) extraction and differential salt precipitation from the source tissue; 2) ion exchange; 3) gel filtration; 4) ion exchange; 5) isoelectric focusing; 6) hydrophobic reverse phase chromatography. The product is useful in the promotion of cell division (mitogenesis) such as in the promotion of wound healing.
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