发明公开
EP0138616A3 Nona- and dodecapeptides for augmenting natural killer cell activity, processes for making them and pharmaceutical compositions comprising them
失效
用于培养自然杀伤细胞活性的非特异性和多态性，制备它们的方法和包含它们的药物组合物
- 专利标题： Nona- and dodecapeptides for augmenting natural killer cell activity, processes for making them and pharmaceutical compositions comprising them
- 专利标题（中）： 用于培养自然杀伤细胞活性的非特异性和多态性，制备它们的方法和包含它们的药物组合物
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申请号： EP84307090申请日： 1984-10-16
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公开(公告)号： EP0138616A3公开(公告)日： 1987-06-16
- 发明人: Nestor, John J. , Moffatt, John G. , Sims, John M.
- 申请人： SYNTEX (U.S.A.) INC.
- 专利权人： SYNTEX (U.S.A.) INC.
- 当前专利权人： SYNTEX (U.S.A.) INC.
- 优先权： US542632 19831017
- 主分类号： C07K07/06
- IPC分类号： C07K07/06 ; C07K07/08 ; A61K37/02 ; C12N15/00
摘要：
Nonapeptides and dodecapeptides of the formula
wherein X is N-acyl-(1-6C)-Gln, or N-acyl-11-6C)-Cys-Tyr-Cys-Gln- or pyro-glutamic acid and Y is Gly, Glu, GlyN(R) 2 or Glu-N(R) 2 wherein R is hydrogen or alkyl of 1 to 6 carbon atoms and the pharmaceutically acceptable, nontoxic salts thereof, which augment natural killer cell activity.
wherein X is N-acyl-(1-6C)-Gln, or N-acyl-11-6C)-Cys-Tyr-Cys-Gln- or pyro-glutamic acid and Y is Gly, Glu, GlyN(R) 2 or Glu-N(R) 2 wherein R is hydrogen or alkyl of 1 to 6 carbon atoms and the pharmaceutically acceptable, nontoxic salts thereof, which augment natural killer cell activity.
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