公开(公告)号：EP0162414A3

公开(公告)日：1987-12-09

申请号：EP85105990

申请日：1985-05-15

申请人： Research Corporation

发明人： Segrest, Jere P. ,  Anantharamaiah, Gattadahalli M.

IPC分类号： C07K07/08 ,  A61K37/02

CPC分类号： C07K14/775 ,  A61K38/00

摘要： A peptide capable of forming an amphipathic helix containing a sequence comprising
wherein
A,, A 2 , A 3 and A 4 are independently aspartic acid or glutamic acid, or homologues or analogues thereof; B,, B 2 , B 3 , B 4 , B 5 , B 6 , B 7 , B 7 , and B 9 are independently tryptophan, phenylalanine, leucine, alanine, tyrosine, isoleucine, valine or α-naphthylalanine, or homologues or analogues thereof; C 1 , C 2 , C 3 , and C 4 are independently lysine or arginine, or homologues, or analogues thereof, and D is serine, threonine, alanine, glycine, or histidine; provided that, when A, and A 2 are aspartic acid, A 3 and A 4 are glutamic acid, B 2 and B 7 are leucine B 3 and B 9 are phenylalanine, B 4 is tyrosin B 5 is valine, C,, C 2 , C 3 , and C 4 are lysine, B 6 , B 6 , and D are alanine, B, is not tryptophan, and a pharmaceutical composition containing said peptide.

公开(公告)号：EP0182372A3

公开(公告)日：1988-09-14

申请号：EP85114743

申请日：1985-11-19

申请人： SCRIPPS CLINIC AND RESEARCH FOUNDATION

发明人： Zimmerman, Theodore S. ,  Fulcher, Carol A.

IPC分类号： C07K15/00 ,  C07K07/10 ,  C07K07/08 ,  C07K03/10 ,  A61K37/02

CPC分类号： C07K16/36 ,  A61K38/00 ,  C07K14/755 ,  Y10S930/10

摘要： Active factor VIII: C coagulant polypeptides identified by partial amino acid sequences are disclosed.

摘要翻译： 活性因子VIII：公开了由部分氨基酸序列鉴定的C凝血剂多肽。

公开(公告)号：EP0175360A3

公开(公告)日：1988-03-30

申请号：EP85111823

申请日：1985-09-18

申请人： CETUS CORPORATION

发明人： Mc Cormick, Francis P. ,  Clark, Robin ,  Nitecki, Danute E. ,  Wong, Gail L. ,  Arnheim, Norman

IPC分类号： C07K15/00 ,  G01N33/574 ,  C07K07/08

CPC分类号： C07K14/82 ,  A61K38/00 ,  G01N33/531 ,  Y10S435/81 ,  Y10S435/961 ,  Y10S436/808 ,  Y10S436/813

摘要： Antibodies exhibit specificity toward single amino acid differences between proteins. These antibodies may be produced by synthesizing a peptide of the appropriate amino acid sequence contained in the protein, immunizing a host with the peptide, and extracting sera from the host to obtain the antibodies. The antibodies and the desired protein are then immunoprecipiated under conditions of partial denaturation to expose the epitope of the protein. The antibodies may be used for diagnostic or therapeutic purposes.

公开(公告)号：EP0155146A3

公开(公告)日：1988-01-20

申请号：EP85301588

申请日：1985-03-07

申请人： SCRIPPS CLINIC AND RESEARCH FOUNDATION

发明人： Milich, David R. ,  Chisari, Frank V.

IPC分类号： A61K39/29 ,  C07K07/08 ,  G01N33/576 ,  C07K07/06 ,  C07K07/10 ,  C12Q01/70

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2730/10122

摘要： Chemically synthesized polypeptides include amino acid residue sequences that substantially correspond to the amino acid residue sequences of T cell and B cell determinant portions of a natural, pathogen-related protein, in particular, a hepatitis B virus surface antigen (HBsAg). When administered to a host alone, as polymers or as carrier-bound conjugates, the polypeptides induce the proliferation of thymus-derived cells in hosts primed against hepatitis B virus.

公开(公告)号：EP0142487A3

公开(公告)日：1986-04-30

申请号：EP84870149

申请日：1984-11-09

申请人： WASHINGTON UNIVERSITY

发明人： Needleman, Philip

IPC分类号： C07K07/08 ,  C07K07/10 ,  A61K37/02

CPC分类号： C07K14/58 ,  A61K38/00 ,  Y10S514/929

摘要： Novel atrial peptides having useful natriuretic activity are disclosed with the following amino acid sequence:
R 1 -cys-phe-gly-gly-arg-ile-asp-arg-ile-gly-ela-gln-ser- gly-leu-gly-cys-asn-R 2 wherein R, = H, ser, ser-ser, and R 2 = OH, ser, ser-phe-arg, ser-phe-arg-tyr, or the physiologically acceptable salts, esters or amides thereof.

公开(公告)号：EP0170496A3

公开(公告)日：1987-11-25

申请号：EP85305279

申请日：1985-07-24

申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： Schmidt, M. Alexander ,  Schoolnik, Gary K. ,  O'Hanley, Peter

IPC分类号： A61K37/02 ,  A61K39/385 ,  C07K07/06 ,  C07K07/08 ,  C07K13/00 ,  C12N15/00

CPC分类号： C07K14/245 ,  A61K38/00 ,  Y10S530/806 ,  Y10S530/81 ,  Y10S530/812

摘要： A vaccine effective in protecting mammals against urinary tract infections is prepared from synthetic peptides substantially equivalent to short sequences contained in HU849 pilin conjugated to substantially antigenically neutral carriers or from a CNBrII fragment of HU849 pilin.

摘要翻译： 从有效保护哺乳动物免受尿路感染的疫苗由与基本上抗原性中性载体缀合的HU849 pilin中包含的短序列或HU849 pilin的CNBrII片段基本相同的合成肽制备。

公开(公告)号：EP0138616A3

公开(公告)日：1987-06-16

申请号：EP84307090

申请日：1984-10-16

申请人： SYNTEX (U.S.A.) INC.

发明人： Nestor, John J. ,  Moffatt, John G. ,  Sims, John M.

IPC分类号： C07K07/06 ,  C07K07/08 ,  A61K37/02 ,  C12N15/00

CPC分类号： C07K14/57 ,  A61K38/00

摘要： Nonapeptides and dodecapeptides of the formula
wherein X is N-acyl-(1-6C)-Gln, or N-acyl-11-6C)-Cys-Tyr-Cys-Gln- or pyro-glutamic acid and Y is Gly, Glu, GlyN(R) 2 or Glu-N(R) 2 wherein R is hydrogen or alkyl of 1 to 6 carbon atoms and the pharmaceutically acceptable, nontoxic salts thereof, which augment natural killer cell activity.

摘要翻译： 式X-Asp-Pro-Tyr-Val-Lys-Glu-Ala-Y（I）的非肽和十二肽...其中... 或焦谷氨酸，Y是Gly，Glu，GlyN（R） 2或GluN（R）2，其中R是氢或1至6个碳原子的烷基和其药学上可接受的无毒盐，这增加了自然杀伤细胞的活性。

公开(公告)号：EP0124779A3

公开(公告)日：1986-07-09

申请号：EP84103819

申请日：1984-04-06

申请人： THE GEORGE WASHINGTON UNIVERSITY

发明人： Goldstein, Allan L. ,  McClure, John ,  Low, Teresa L. K. ,  Naylor, Paul H.

IPC分类号： G01N33/534 ,  G01N33/74 ,  C07K07/08

CPC分类号： G01N33/74 ,  Y10S436/804 ,  Y10S436/815 ,  Y10S930/18

摘要： Es wird ein Radiommunverfahren zur Bestimmung von Thymosin β₄ beschrieben. Das Verfahren besteht darin, dass man die Probe mit einer bekannten menge von radioaktiv markiertem Tyr-C13-thymosin β₄ und einem Antikörper gegen Thymosin β₄ versetzt, den Antigen/Antikörper- Komplex vom ungebundenen radioaktiv markierten Thymo sin β₄ abtrennt, das Ausmass der Radioaktivität im Antigen/Antikörper-Komplex bestimmt und mit einer Stan dardkurve vergleicht.

公开(公告)号：EP0103858A3

公开(公告)日：1985-09-04

申请号：EP83109147

申请日：1983-09-16

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： Hashimoto, Masashi ,  Hemmi, Keiji ,  Hagiwara, Daijiro

IPC分类号： C07K07/06 ,  C07K07/08 ,  A61K37/02

CPC分类号： C07K7/062 ,  A61K38/00 ,  C07K14/42 ,  C07K14/57581 ,  C07K14/66

摘要： A peptide selected from the group consisting of a peptide of the following formulae: an d a pharmaceutically acceptable salt thereof, processes for pr eparation thereof and pharmaceutical compositions con- ta ining them.

公开(公告)号：EP0206118A3

公开(公告)日：1988-12-14

申请号：EP86107957

申请日：1986-06-11

申请人： MERCK & CO. INC.

发明人： Nutt, Ruth F.

IPC分类号： C07K07/64 ,  C07K07/66 ,  A61K37/02 ,  C07K07/08

CPC分类号： C07K14/6555 ,  A61K38/00 ,  Y10S514/806 ,  Y10S930/16

摘要： somatostatin analogs are prepared wherein a cyclic hexapeptide contains a secondary amino acid which replaces seven of the ring amino acids of somatostatin. The cyclic hexapeptides are easier to synthesize, have a longer duration of activity, and many have a greater level of activity than somatostatin. The compounds have the properties of inhibiting the release of glucagon, growth hormone and insulin. Certain of the compounds also are capable of inhibiting the release of gastric acid secretions. The compounds are particularly useful in the treatment of acromegaly, diabetes, diabetic retinopathy and peptic ulcers. These cyclic hexapeptides are prepared by the solid phase method and/or solution synthesis.