发明公开
EP0153114A3 Monoclonal anti-human breast cancer antibodies, their production and use, and hybridomas for producing the same and their preparation
失效
单克隆抗人乳腺癌抗体，其生产和使用，以及用于生产其的混合物及其制备
- 专利标题： Monoclonal anti-human breast cancer antibodies, their production and use, and hybridomas for producing the same and their preparation
- 专利标题（中）： 单克隆抗人乳腺癌抗体，其生产和使用，以及用于生产其的混合物及其制备
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申请号： EP85300877申请日： 1985-02-08
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公开(公告)号： EP0153114A3公开(公告)日： 1985-10-09
- 发明人: Frankel, Arthur Edward , Bjorn, Michael Jon , Ring, David Baratt
- 申请人： CETUS CORPORATION
- 专利权人： CETUS CORPORATION
- 当前专利权人： CETUS CORPORATION
- 优先权： US577976 19840208; US690750 19850111
- 主分类号： C12P21/00
- IPC分类号： C12P21/00 ; C12N05/00 ; C12N15/00 ; A61K39/395 ; G01N33/577 ; C12R01/31
摘要：
Murine monocionai antibodies are prepared and characterized which bind selectively to human breast cancer cells, are Ig G8 or IgMs, and when conjugated to ricin A chain, exhibit a TCID 50% against at least one of MCF-7, CAMA-1, SKBR-3, or BT-20 cells of less than about 10 nM. Methods for diagnosing, monitoring, and treating human breast cancer with the antibodies or immunotoxins made therefrom are descirbed.
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