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1.发明公开Monoclonal anti-human breast cancer antibodies, their production and use, and hybridomas for producing the same and their preparation 失效单克隆抗人乳腺癌抗体，其生产和使用，以及用于生产其的混合物及其制备
公开(公告)号：EP0153114A3
公开(公告)日：1985-10-09
申请号：EP85300877
申请日：1985-02-08
申请人： CETUS CORPORATION
IPC分类号： C12P21/00 , C12N05/00 , C12N15/00 , A61K39/395 , G01N33/577 , C12R01/31
CPC分类号： C07K16/3015 , A61K38/00 , C07K2317/24 , C07K2317/622 , Y10S424/804 , Y10S435/948 , Y10S530/808 , Y10S530/861 , Y10S530/864
摘要： Murine monocionai antibodies are prepared and characterized which bind selectively to human breast cancer cells, are Ig G8 or IgMs, and when conjugated to ricin A chain, exhibit a TCID 50% against at least one of MCF-7, CAMA-1, SKBR-3, or BT-20 cells of less than about 10 nM. Methods for diagnosing, monitoring, and treating human breast cancer with the antibodies or immunotoxins made therefrom are descirbed.
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2.发明公开Monoclonal anti-human breast cancer antibodies, their production and use, and hybridomas for producing the same and their preparation 失效单克隆抗体对人类乳腺癌，其生产和使用，为他们这些杂交瘤的制备和生产杂交瘤。
公开(公告)号：EP0153114A2
公开(公告)日：1985-08-28
申请号：EP85300877.9
申请日：1985-02-08
申请人： CETUS CORPORATION
IPC分类号： C12P21/00 , C12N5/00 , C12N15/00 , A61K39/395 , G01N33/577
CPC分类号： C07K16/3015 , A61K38/00 , C07K2317/24 , C07K2317/622 , Y10S424/804 , Y10S435/948 , Y10S530/808 , Y10S530/861 , Y10S530/864
摘要： Murine monocionai antibodies are prepared and characterized which bind selectively to human breast cancer cells, are Ig G8 or IgMs, and when conjugated to ricin A chain, exhibit a TCID 50% against at least one of MCF-7, CAMA-1, SKBR-3, or BT-20 cells of less than about 10 nM. Methods for diagnosing, monitoring, and treating human breast cancer with the antibodies or immunotoxins made therefrom are descirbed.
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3.发明授权Monoclonal anti-human breast cancer antibodies, their production and use, and hybridomas for producing the same and their preparation 失效单克隆抗人乳腺癌抗体，其生产和使用，以及用于生产它们的混合物及其制备
公开(公告)号：EP0153114B1
公开(公告)日：1989-07-19
申请号：EP85300877.9
申请日：1985-02-08
申请人： CETUS CORPORATION
IPC分类号： C12P21/00 , C12N5/00 , C12N15/00 , A61K39/395 , G01N33/577
CPC分类号： C07K16/3015 , A61K38/00 , C07K2317/24 , C07K2317/622 , Y10S424/804 , Y10S435/948 , Y10S530/808 , Y10S530/861 , Y10S530/864
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