发明公开
EP0158282A3 Vaccine and serum for endotoxin associated disease and method of preparing same as well as methods of immunisation and treatment of such disease and to a detoxified endotoxin and bacterial mutant
失效
用于内毒素相关疾病的疫苗和血清及其制备方法以及作为这种疾病的免疫和治疗方法以及脱氧内毒素和细菌突变体
- 专利标题： Vaccine and serum for endotoxin associated disease and method of preparing same as well as methods of immunisation and treatment of such disease and to a detoxified endotoxin and bacterial mutant
- 专利标题（中）： 用于内毒素相关疾病的疫苗和血清及其制备方法以及作为这种疾病的免疫和治疗方法以及脱氧内毒素和细菌突变体
-
申请号： EP85104085申请日： 1985-04-03
-
公开(公告)号： EP0158282A3公开(公告)日： 1988-05-25
- 发明人: Sprouse, Ronald F. , Garner, Harold E.
- 申请人： THE CURATORS OF THE UNIVERSITY OF MISSOURI
- 专利权人： THE CURATORS OF THE UNIVERSITY OF MISSOURI
- 当前专利权人： THE CURATORS OF THE UNIVERSITY OF MISSOURI
- 优先权： US597115 19840405; US697008 19850131
- 主分类号： A61K39/112
- IPC分类号： A61K39/112 ; A61K39/40 ; A61K39/02
摘要：
A combination vaccine, with methods of preparation and treatment, for protection against Gram negative bacterial diseases. The vaccine includes a killed suspension of a bacterial mutant from the taxonomic family Enterobacteriaceae, a B-lymphocyte proliferating immune modulator, and a protein and lipid binding adjuvant. A hyperimmune serum for treating diseased animals is prepared by vaccinating a donor animal with the combination vaccine and then preparing clot serum containing antigen specific antibodies. The mutant is ATCC No. 53000 and is produced by ionizing radiation of Salmonella enteritidis. The immune modulator is a detoxified extract of lipopolysaccharide and is useful with many antigens to enhance primary immune response.
信息查询
